Cancer Therapeutics
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Recent papers in Cancer Therapeutics
DNA repair vulnerabilities are present in a significant proportion of cancers. Specifically, germline alterations in DNA repair not only increase cancer risk but are associated with treatment response and clinical outcomes. The... more
Glutathione (GSH) is an important intracellular antioxi dant that instills several vital roles within a cell including maintenance of the redox state, drug detoxification, and cellular protection from damage by free radicals, peroxi des... more
Cancer progression is a polygenic procedure in which the exosomes can function as substantial roles. Exosomes are tiny, phospholipid bilayer membrane nanovesicles of endocytic derivation with a diameter of 40–100 nm. These nanovesicles... more
Peripheral cemento-ossifying fibroma (PCOF) is a reactive neoplasm. It occurs frequently in anterior maxilla comprises 9% of all gingival growths and predominantly affects adolescents and young adults. It most commonly arises from the... more
The objective was to quantify the accuracy of dose calculation for out-of-field regions by the commercially available TiGRT version 1.2 (LinaTech, Sunnyvale, CA, USA) treatment planning system (TPS) for a clinical treatment delivered on a... more
Dear Sir/Madam We are currently hosting the Oncologist & Diagnostics Conference which is going to be organized during August 28-30, 2017 Brussels, Belgium. With great pride and honour, we would like to invite you to participate in... more
Background: Intensity-modulated radiotherapy using simultaneous integrated boost (SIB-IMRT) is an attractive method for the treatment of head and neck cancers with sparing of the salivary function. Aims: To assess the feasibility,... more
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and one of the prominent causes of cancer mortality, leading to approximately 780,000 deaths per year worldwide. Down-regulation of microRNA-125b (miR-125b)... more
Objective: To assess the chemotherapeutic effect of Allyl disulfide (garlic extract) on 1, 4-Dioxane-induced hepatocarcinogenesis in BALB/c mice. Methods: Mice were divided into four groups; group I was taken as negative control and... more
To study the clinico-radiological and clinic-pathological features of orbital alveolar soft-part sarcomas (ASPS). We retrieved 9 cases of orbital ASPS. Histopathological and immunohistochemical features and clinico-radiological findings... more
Hyperhomocysteinemia is reported to be associated with an increase in the incidence of ischemic heart disease and cerebrovascular disease. Genetic aberrations in methylenetetrahydrofolate reductase (MTHFR) may account for reduced enzyme... more
Purpose: To evaluate the role of positron emission tomography (PET) for predicting the clinical outcome of patients with recurrent cervical carcinoma following definitive radiation therapy (RT). Materials and Methods: Twenty two patients... more
Background/Aim. Melanoma is the most aggresive malignant tumor of the skin. Contradictory data was published on vascular endothelial growth factor (VGEF) in tumor samples and its role in skin melanoma progression and prognosis. The aim of... more
I get a creeping sense of subcutaneous unease that something is not quite right. There is fundamental misunderstanding about the role of genes in the healthy development of eggs to embryos and adults. Unfortunately, this abuse of the... more
In the current study, the effect of electronic disequilibrium on lung dose with small photon beams was verified. The central axis absorbed dose in lung phantom was calculated by Monte Carlo (MC) method. The 6 and 18 MV photon beams of... more
The adhesive glycophosphoprotein (OPN) is capable of inducing metastasis in rodent models ofbreast cancer. We now show that a monoclonal antibody to rat OPN recognizes specifically human OPN using Western blotting techniques andused it to... more
Background: Quality of Life (QOL) measures have now become a vital part of health outcome appraisal and an effective way of capturing the personal and social context of patients. Aim: To assess the QOL of cancer patients by using a... more
To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin. Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410;... more
Anticancer properties of artemisinin and its derivatives have been shown in many experiments. Addition of butyric acid, miconazole, and iron to this traditional drug has been done in order to enhance its anticancer potency. Cell lines... more