Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
BioDiscovery
Cardiovascular drugs and therapy
Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System2018 •
Perivascular adipose tissue (PVAT) refers to the local aggregate of adipose tissue surrounding the vascular tree, exhibiting phenotypes from white to brown and beige adipocytes. Although PVAT has long been regarded as simply a structural unit providing mechanical support to vasculature, it is now gaining reputation as an integral endocrine/paracrine component, in addition to the well-established modulator endothelium, in regulating vascular tone. Since the discovery of anti-contractile effect of PVAT in 1991, the use of multiple rodent models of reduced amounts of PVAT has revealed its regulatory role in vascular remodeling and cardiovascular implications, including atherosclerosis. PVAT does not only release PVAT-derived relaxing factors (PVRFs) to activate multiple subsets of endothelial and vascular smooth muscle potassium channels and anti-inflammatory signals in the vasculature, but it does also provide an interface for neuron-adipocyte interactions in the vascular wall to regu...
Perivascular adipose tissue (PVAT) is a specialized type of adipose tissue that surrounds most mammalian blood vessels. PVAT is a metabolically active, endocrine organ capable of regulating blood vessel tone, endothelium function, vascular smooth muscle cell growth and proliferation, and contributing critically to cardiovascular disease onset and progression. In the context of vascular tone regulation, under physiological conditions, PVAT exerts a potent anticontractile effect by releasing a plethora of vasoactive substances, including NO, H2S, H2O2, prostacyclin, palmitic acid methyl ester, angiotensin 1-7, adiponectin, leptin, and omentin. However, under certain pathophysiological conditions, PVAT exerts pro-contractile effects by decreasing the production of anticontractile and increasing that of pro-contractile factors, including superoxide anion, angiotensin II, catecholamines, prostaglandins, chemerin, resistin, and visfatin. The present review discusses the regulatory effect ...
Mediators of Inflammation
Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular PathologiesInitially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocytokines such as adiponectin, nitric oxide, and omentin. However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1β, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascular diseases. In this review, current knowledge on the role of PVAT inflammation in the development of vascular pathologies such as atherosclerosis and hypertension was discussed.
The Anatolian Journal of Cardiology
Perivascular adipose tissue in cardiovascular diseases – an update2019 •
2011 •
Arteriosclerosis, Thrombosis, and Vascular Biology
Perivascular Adipose Tissue and Coronary Vascular Disease2014 •
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capable of producing local factors with the potential to augment coronary vascular tone, inflammation, and the initiation and progression of coronary artery disease. The purpose of the present review is to outline previous findings about the cardiovascular effects of coronary perivascular adipose tissue and the potential mechanisms by which adipose-derived factors may influence coronary vascular function and the progression of atherogenesis.
2015 •
Ge-conservacion
Presentación "III Congreso Iberoamericano de Investigaciones en Conservación del Patrimonio (ICP)2021 •
Educação: processo contínuo de desenvolvimento
EDUCAÇÃO FINANCEIRA PARA JOVENS E ADULTOS: construindo um caderno de receitas2021 •
Semantic Struggles in Roman Antiquity?
Semantic Struggles in Roman Antiquity? Review of Marian Nebelin and Claudia Tiersch, eds., Semantische Kämpfe zwischen Republik und Prinzipat? Kontinuität und Transformation der politischen Sprache in Rom , Göttingen 2021 in: Contributions to the History of Concepts 18(2), 130-1352023 •
FUDMA JOURNAL OF POLITICS AND INTERNATIONAL AFFAIRS
Corruption and its Effects on Economic, Political, Social and Cultural Development of Nigerians in the Fourth Republic2020 •
2010 IEEE International Geoscience and Remote Sensing Symposium
Long time series of Landsat images to reconstruct River surface temperature and turbidity regimes of Guadalquivir Estuary2010 •
2019 •
2011 •
International Journal of Coal Geology
Middle Permian environmental changes and shale oil potential evidenced by high-resolution organic petrology, geochemistry and mineral composition of the sediments in the Santanghu Basin, Northwest China2018 •
bioRxiv (Cold Spring Harbor Laboratory)
Mutation of the<i>P. falciparum</i>flavokinase confers resistance to roseoflavin and 8-aminoriboflavin2024 •
The Pharma Innovation Journal
Effect of commercial drug nakku poochi (kolli) kudineer chooranum in Haemonchus contortus2018 •
Photodiagnosis and photodynamic therapy
Hypericin-assisted photodynamic therapy against anaplastic thyroid cancer2018 •
Journal of Machine Engineering
Improved Machining Performance Through Turn-Milling2022 •
Lecture Notes in Computer Science
The SPIRIT Spatial Search Engine: Architecture, Ontologies and Spatial Indexing2004 •