Objective: The pathogenesis of periodontal disease although widely studied presents controversial points. Thus the aim of this study was to analyze the dynamics of the inflammatory genes expression related to the tissue destruction and attachment loss in a periodontitis experimental model. Method: Fifteen male Wistar rats had the first mandibular molar ligated to induce periodontitis. The animals were killed in different time points and divided into five groups: day one (D1), day three (D3), day five (D5), day seven (D7) and control group (without ligature). Three gingival biopsies from each group were harvested for the expression analysis of the inflammatory genes (IL1β, IL12, IL4, COX2, MMP8, MMP9 and IL17) by Real Time PCR. The differences among groups were verified with ANOVA and Tukey´s test (p<0.05). Result: We observed a higher expression of IL1β in D1 (p<0.01) with a decrease in D3 (p<0.01), D5 (p<0.01) and D7 (p<0.01). The expression of IL4 and IL12 were down...
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