Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers. Epidemiological findings combined with newly discovered mechanisms suggest a new model of cancer etiology that accounts for these actions of 25(OH)D and calcium. Its seven phases are disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition (abbreviated DINOMIT). Vitamin D metabolites prevent disjunction of cells and are beneficial in other phases. It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such ...

Cancer mortality rates vary inversely with geographic latitude and solar ultraviolet-B doses. This relationship may be due to an inhibitory role of vitamin D on cancer development. The relationship between vitamin D and cancer appears to be stronger for studies of cancer mortality than incidence. Because cancer mortality reflects both cancer incidence and survival, the difference may be due to effects of vitamin D on cancer survival. Here we review analytic epidemiologic studies investigating the relation between vitamin D, measured by circulating levels of 25-hydroxyvitamin D (25-OHD), and cancer survival. A relationship between low 25-OHD levels and poor survival is shown by most of the reviewed studies. This relationship is likely to be causal when viewed in light of most criteria for assessing causality (temporality, strength, exposure-response, biological plausibility and consistency). A serum level of 25-OHD around 50 nmol/L appears to be a threshold level. Conversely, there a...

Sound level meter (SLM) calibration according to IEC61672-1, 2, 3: 2013 is an essential step in the measurement process. It ensures that the SLM meets its specifications. There is a strong need for an efficient and cheap calibration system device for the electrical calibration of SLM since it avoids the body effect and angle sensitivity of the microphone membrane to the sound incidence angle for free field calibration. As well as, it avoids leakage errors due to the microphone fitting in the coupler and the coupler effect in pressure field calibration. This work gives an alternative system device used in the electrical calibration of SLM. This system consists of individual tools; PULSE signal generator, universal frequency counter, HP Dynamic signal analyzer, and DMM voltmeter. All system tools are complying with the IEC17025. The calibration procedures follow the second edition of IEC61672-2. Calibration measurements of frequency, time-weightings, and linearity of range parameters as the major features of SLMs are tested in the frequency range of 31.5 Hz to 16 k Hz. The calibration was repeated 5 times on different days and different warm-up times for devices to estimate the associated uncertainty measurement values in accordance with Part 2 and Part 3 of IEC 61672. The obtained results show that, the calibration measurement deviations are in the allowable tolerance of the IEC 61672-1 and they are comparable with that obtained from the primary Brüel & Kjaer (B & K) platform 3630. The computed uncertainty of measurements is in accepted limits that are required by IEC 61672-1 which is determined to the level of confidence of 95%, using coverage factor 2.

Satuan Pendidikan : SMK/MAK Mata Pelajaran : TEKNOLOGI DASAR OTOMOTIF (tdo) Kelas/Semester : X Kompetensi Inti : 1. Menghayati dan mengamalkan ajaran agama yang dianutnya. 2. Menghayati dan Mengamalkan perilaku jujur, disiplin, tanggung jawab, peduli (gotong royong, kerjasama, toleran, damai), santun, responsif dan proaktif dan menunjukan sikap sebagai bagian dari solusi atas berbagai permasalahan dalam berinteraksi secara efektif dengan lingkungan sosial dan alam serta dalam menempatkan diri sebagai cerminan bangsa dalam pergaulan dunia. 3. Memahami, menerapkan dan menganalisis pengetahuan faktual, konseptual dan prosedural berdasarkan rasa ingin tahunya tentang ilmu pengetahuan, teknologi, seni, budaya, dan humaniora dalam wawasan kemanusiaan, kebangsaan, kenegaraan, dan peradaban terkait penyebab fenomena dan kejadian dalam bidang kerja yang spesifik untuk memecahkan masalah. 4. Mengolah, menalar, dan menyaji dalam ranah konkret dan ranah abstrak terkait dengan pengembangan dari yang dipelajarinya di sekolah secara mandiri, dan mampu melaksanakan tugas spesifik dibawah pengawasan langsung.