Xue, Bo*; Farghaly, Ahmed A*.; Guo, Zhenzhao; Zhao, Peng; Li, Hong; Zhou, Changren; Li, Lihua
Equ... more Xue, Bo*; Farghaly, Ahmed A*.; Guo, Zhenzhao; Zhao, Peng; Li, Hong; Zhou, Changren; Li, Lihua Equally Contributed. Calcium phosphate cement (CPC) has been used for bone restoration despite its intrinsic fragile property. In order to enhance the CPC mechanical properties, biopolymers were introduced as filler to prepare CPC based cements. Chitosan/tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) based cement for bone repair has been prepared in the study. Solidification of the prepared cement was carried out in a simulate body fluid at 37 °C. The introduction of chitosan improved the mechanical performance of the as-prepared CPC hybrid nanocomposite. FTIR, SEM, TEM, HRTEM, XRD, and SAED were used to characterize the CPC nanocomposite. Data simulations have been performed to assist in determining the crystalline phase/s in the CPC hybrid nanocomposite. Based on the SAED, HRTEM measurements and data simulations, a monoclinic phase of hydroxyapatite (HAP) with a plate-like structure was obtained in the CPC system, which is believed to be responsible for the observed enhancement in CPC mechanical properties. The obtained composite has a biocompatibility comparable to that of commercial sample.
Lignin is a high volume byproduct produced from the pulp and paper industry. Most of lignin is cu... more Lignin is a high volume byproduct produced from the pulp and paper industry. Most of lignin is currently burned to generate electricity. The industry has been searching for high value added usage of lignin to improve the process economics. . On the other hand, sustainable energy supplies depends on the progress of green technologies needs to be developed urgently which can be achieved via environmentally friendly approaches with inexpensive precursors and rich resources obtained from bio-mass. These materials has recently been employed in the field of energy such as fuel cells and supercapacitors In this work, lignin biomass which is a cross-linked polymer of phenols is converted into N-doped porous carbon using a two-step conversion process. Lignin is first converted into biochar via hydrothermal carbonization at 300 °C and 1500 psi using very unique reactor which is capable of applying sonication to biomass at high T,P. Then, N-doped porous carbons were obtained by mixing biochar ...
Photolithographic Micropatterning of Conducting Polymers on Flexible Silk Matrices
http://onlinelibrary.wiley.com/wol1/doi/10.1002/adma.201504736/abstract
High-resolution micropatt... more http://onlinelibrary.wiley.com/wol1/doi/10.1002/adma.201504736/abstract High-resolution micropatterning of a conducting polymer-silk sericin composite, poly(3, 4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS), is presented using a water-based, benchtop photolithographic process. Conducting microstructures formed on a flexible silk fibroin sheet allow a fully organic, flexible bioelectronic device. Large area microfabricated devices such as biosensors can be formed that are biocompatible and degradable over a controlled period of time.
Potentiometric Measurements in Biofouling Solutions: Comparison of Nanoporous Gold to Planar Gold
http://jes.ecsdl.org/content/163/4/H3083.short?rss=1
Potentiometric redox measurements were made ... more http://jes.ecsdl.org/content/163/4/H3083.short?rss=1 Potentiometric redox measurements were made in solutions of increasing biological complexity starting with buffer solutions containing either potassium ferri/ferrocyanide or ascorbic acid and finishing with plasma and blood. When the concentration of ferri/ferrocyanide was high (∼0.2 mM), both biofouled planar and nanoporous gold electrodes gave Nernstian slopes of 55–59 mV. However, at or below a critical concentration (≤ 0.1 mM), ∼20% loss in sensitivity was observed at planar gold in contrast to nanoporous gold where Nernstian behavior was retained. For ascorbic acid, a Nernst slope of −41 mV was observed at biofouled nanoporous gold electrodes. In contrast, biofouled planar gold electrodes failed to give any potentiometric redox response. At all concentrations studied, cyclic voltammetric measurements on biofouled electrodes revealed significant impairment of faradaic electroactivity at planar gold electrodes while no impairment was shown at nanoporous gold. These results indicate that nanoporous gold is an ideal electrode material to use when making both potentiometric and cyclic voltammetric measurements, particularly in complex solutions containing relatively low concentrations of redox molecules. As proof of concept, the redox potential of plasma and blood has been measured using nanoporous and planar gold electrodes and their values compared.
Xue, Bo*; Farghaly, Ahmed A*.; Guo, Zhenzhao; Zhao, Peng; Li, Hong; Zhou, Changren; Li, Lihua
Equ... more Xue, Bo*; Farghaly, Ahmed A*.; Guo, Zhenzhao; Zhao, Peng; Li, Hong; Zhou, Changren; Li, Lihua Equally Contributed. Calcium phosphate cement (CPC) has been used for bone restoration despite its intrinsic fragile property. In order to enhance the CPC mechanical properties, biopolymers were introduced as filler to prepare CPC based cements. Chitosan/tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) based cement for bone repair has been prepared in the study. Solidification of the prepared cement was carried out in a simulate body fluid at 37 °C. The introduction of chitosan improved the mechanical performance of the as-prepared CPC hybrid nanocomposite. FTIR, SEM, TEM, HRTEM, XRD, and SAED were used to characterize the CPC nanocomposite. Data simulations have been performed to assist in determining the crystalline phase/s in the CPC hybrid nanocomposite. Based on the SAED, HRTEM measurements and data simulations, a monoclinic phase of hydroxyapatite (HAP) with a plate-like structure was obtained in the CPC system, which is believed to be responsible for the observed enhancement in CPC mechanical properties. The obtained composite has a biocompatibility comparable to that of commercial sample.
Lignin is a high volume byproduct produced from the pulp and paper industry. Most of lignin is cu... more Lignin is a high volume byproduct produced from the pulp and paper industry. Most of lignin is currently burned to generate electricity. The industry has been searching for high value added usage of lignin to improve the process economics. . On the other hand, sustainable energy supplies depends on the progress of green technologies needs to be developed urgently which can be achieved via environmentally friendly approaches with inexpensive precursors and rich resources obtained from bio-mass. These materials has recently been employed in the field of energy such as fuel cells and supercapacitors In this work, lignin biomass which is a cross-linked polymer of phenols is converted into N-doped porous carbon using a two-step conversion process. Lignin is first converted into biochar via hydrothermal carbonization at 300 °C and 1500 psi using very unique reactor which is capable of applying sonication to biomass at high T,P. Then, N-doped porous carbons were obtained by mixing biochar ...
Photolithographic Micropatterning of Conducting Polymers on Flexible Silk Matrices
http://onlinelibrary.wiley.com/wol1/doi/10.1002/adma.201504736/abstract
High-resolution micropatt... more http://onlinelibrary.wiley.com/wol1/doi/10.1002/adma.201504736/abstract High-resolution micropatterning of a conducting polymer-silk sericin composite, poly(3, 4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS), is presented using a water-based, benchtop photolithographic process. Conducting microstructures formed on a flexible silk fibroin sheet allow a fully organic, flexible bioelectronic device. Large area microfabricated devices such as biosensors can be formed that are biocompatible and degradable over a controlled period of time.
Potentiometric Measurements in Biofouling Solutions: Comparison of Nanoporous Gold to Planar Gold
http://jes.ecsdl.org/content/163/4/H3083.short?rss=1
Potentiometric redox measurements were made ... more http://jes.ecsdl.org/content/163/4/H3083.short?rss=1 Potentiometric redox measurements were made in solutions of increasing biological complexity starting with buffer solutions containing either potassium ferri/ferrocyanide or ascorbic acid and finishing with plasma and blood. When the concentration of ferri/ferrocyanide was high (∼0.2 mM), both biofouled planar and nanoporous gold electrodes gave Nernstian slopes of 55–59 mV. However, at or below a critical concentration (≤ 0.1 mM), ∼20% loss in sensitivity was observed at planar gold in contrast to nanoporous gold where Nernstian behavior was retained. For ascorbic acid, a Nernst slope of −41 mV was observed at biofouled nanoporous gold electrodes. In contrast, biofouled planar gold electrodes failed to give any potentiometric redox response. At all concentrations studied, cyclic voltammetric measurements on biofouled electrodes revealed significant impairment of faradaic electroactivity at planar gold electrodes while no impairment was shown at nanoporous gold. These results indicate that nanoporous gold is an ideal electrode material to use when making both potentiometric and cyclic voltammetric measurements, particularly in complex solutions containing relatively low concentrations of redox molecules. As proof of concept, the redox potential of plasma and blood has been measured using nanoporous and planar gold electrodes and their values compared.
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Calcium phosphate cement (CPC) has been used for bone restoration despite its intrinsic fragile property. In order to enhance the CPC mechanical properties, biopolymers were introduced as filler to prepare CPC based cements. Chitosan/tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) based cement for bone repair has been prepared in the study. Solidification of the prepared cement was carried out in a simulate body fluid at 37 °C. The introduction of chitosan improved the mechanical performance of the as-prepared CPC hybrid nanocomposite. FTIR, SEM, TEM, HRTEM, XRD, and SAED were used to characterize the CPC nanocomposite. Data simulations have been performed to assist in determining the crystalline phase/s in the CPC hybrid nanocomposite. Based on the SAED, HRTEM measurements and data simulations, a monoclinic phase of hydroxyapatite (HAP) with a plate-like structure was obtained in the CPC system, which is believed to be responsible for the observed enhancement in CPC mechanical properties. The obtained composite has a biocompatibility comparable to that of commercial sample.
High-resolution micropatterning of a conducting polymer-silk sericin composite, poly(3, 4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS), is presented using a water-based, benchtop photolithographic process. Conducting microstructures formed on a flexible silk fibroin sheet allow a fully organic, flexible bioelectronic device. Large area microfabricated devices such as biosensors can be formed that are biocompatible and degradable over a controlled period of time.
Potentiometric redox measurements were made in solutions of increasing biological complexity starting with buffer solutions containing either potassium ferri/ferrocyanide or ascorbic acid and finishing with plasma and blood. When the concentration of ferri/ferrocyanide was high (∼0.2 mM), both biofouled planar and nanoporous gold electrodes gave Nernstian slopes of 55–59 mV. However, at or below a critical concentration (≤ 0.1 mM), ∼20% loss in sensitivity was observed at planar gold in contrast to nanoporous gold where Nernstian behavior was retained. For ascorbic acid, a Nernst slope of −41 mV was observed at biofouled nanoporous gold electrodes. In contrast, biofouled planar gold electrodes failed to give any potentiometric redox response. At all concentrations studied, cyclic voltammetric measurements on biofouled electrodes revealed significant impairment of faradaic electroactivity at planar gold electrodes while no impairment was shown at nanoporous gold. These results indicate that nanoporous gold is an ideal electrode material to use when making both potentiometric and cyclic voltammetric measurements, particularly in complex solutions containing relatively low concentrations of redox molecules. As proof of concept, the redox potential of plasma and blood has been measured using nanoporous and planar gold electrodes and their values compared.
Equally Contributed.
Calcium phosphate cement (CPC) has been used for bone restoration despite its intrinsic fragile property. In order to enhance the CPC mechanical properties, biopolymers were introduced as filler to prepare CPC based cements. Chitosan/tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) based cement for bone repair has been prepared in the study. Solidification of the prepared cement was carried out in a simulate body fluid at 37 °C. The introduction of chitosan improved the mechanical performance of the as-prepared CPC hybrid nanocomposite. FTIR, SEM, TEM, HRTEM, XRD, and SAED were used to characterize the CPC nanocomposite. Data simulations have been performed to assist in determining the crystalline phase/s in the CPC hybrid nanocomposite. Based on the SAED, HRTEM measurements and data simulations, a monoclinic phase of hydroxyapatite (HAP) with a plate-like structure was obtained in the CPC system, which is believed to be responsible for the observed enhancement in CPC mechanical properties. The obtained composite has a biocompatibility comparable to that of commercial sample.
High-resolution micropatterning of a conducting polymer-silk sericin composite, poly(3, 4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS), is presented using a water-based, benchtop photolithographic process. Conducting microstructures formed on a flexible silk fibroin sheet allow a fully organic, flexible bioelectronic device. Large area microfabricated devices such as biosensors can be formed that are biocompatible and degradable over a controlled period of time.
Potentiometric redox measurements were made in solutions of increasing biological complexity starting with buffer solutions containing either potassium ferri/ferrocyanide or ascorbic acid and finishing with plasma and blood. When the concentration of ferri/ferrocyanide was high (∼0.2 mM), both biofouled planar and nanoporous gold electrodes gave Nernstian slopes of 55–59 mV. However, at or below a critical concentration (≤ 0.1 mM), ∼20% loss in sensitivity was observed at planar gold in contrast to nanoporous gold where Nernstian behavior was retained. For ascorbic acid, a Nernst slope of −41 mV was observed at biofouled nanoporous gold electrodes. In contrast, biofouled planar gold electrodes failed to give any potentiometric redox response. At all concentrations studied, cyclic voltammetric measurements on biofouled electrodes revealed significant impairment of faradaic electroactivity at planar gold electrodes while no impairment was shown at nanoporous gold. These results indicate that nanoporous gold is an ideal electrode material to use when making both potentiometric and cyclic voltammetric measurements, particularly in complex solutions containing relatively low concentrations of redox molecules. As proof of concept, the redox potential of plasma and blood has been measured using nanoporous and planar gold electrodes and their values compared.