Papers by Fernando Bedoya
Acta méd. …, 1997
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Acta méd. …, 1997
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Diario La Ley, 2013
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Spain Arbitration Review Revista Del Club Espanol Del Arbitraje, 2011
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Iatreia, Apr 21, 2001
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Acta Med Colomb, Dec 1, 1997
... experimental, Documentos relacionados. Id: 221216. Autor: Tobón, Angela; Franco, Liliana; Cor... more ... experimental, Documentos relacionados. Id: 221216. Autor: Tobón, Angela; Franco, Liliana; Correa, Ana L; Bedoya, Fernando; Ortega, Jorge; Oto, Mónica; Arango, Myrtha; Valencia, Olga L; Restrepo, Angela. Título: La histoplasmosis en el adulto. Bases para su diagnóstico. ...
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PloS one, 2015
The idiopathic inflammatory demyelinating disease (IIDD) spectrum has been investigated among dif... more The idiopathic inflammatory demyelinating disease (IIDD) spectrum has been investigated among different populations, and the results have indicated a low relative frequency of neuromyelitis optica (NMO) among multiple sclerosis (MS) cases in whites (1.2%-1.5%), increasing in Mestizos (8%) and Africans (15.4%-27.5%) living in areas of low MS prevalence. South America (SA) was colonized by Europeans from the Iberian Peninsula, and their miscegenation with natives and Africans slaves resulted in significant racial mixing. The current study analyzed the IIDD spectrum in SA after accounting for the ethnic heterogeneity of its population. A cross-sectional multicenter study was performed. Only individuals followed in 2011 with a confirmed diagnosis of IIDD using new diagnostic criteria were considered eligible. Patients' demographic, clinical and laboratory data were collected. In all, 1,917 individuals from 22 MS centers were included (73.7% female, 63.0% white, 28.0% African, 7.0% M...
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Biomédica : revista del Instituto Nacional de Salud, 2004
Drug resistance has become a major problem in the treatment of tuberculosis. Pulmonary resection ... more Drug resistance has become a major problem in the treatment of tuberculosis. Pulmonary resection in combination with chemotherapy appears to be an effective measure for the treatment of multi-drug resistant pulmonary tuberculosis. A retrospective review was performed of the medical and laboratory findings of 28 patients with multi-drug resistant tuberculosis who underwent pulmonary resection for pulmonary tuberculosis between January 1990 and December 2000 at La Maria Hospital, Medellín. Twenty-one of them had medical therapy before surgery; 14 patients underwent upper lobectomy and 10 patients pneumonectomy). The AFB negative sputum conversion rate was 88.9% (25/27) after surgery, during an average of 6 weeks. Bacteriological relapses were confirmed in 6 of 27, 4 of these 6 had AFB negative sputum. Twenty-eight patients had medical therapy after surgery. For selected patients, pulmonary resection in combination with chemotherapy should be considered an effective measure for treatme...
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Tumori
Cannabinoid receptors have an impact on gastrointestinal function, but it remains unknown whether... more Cannabinoid receptors have an impact on gastrointestinal function, but it remains unknown whether mutations may affect tumor susceptibility in patients with esophageal carcinoma. The aim of this study was to determine mutation in the cannabinoid receptor-1 (CNR1) gene and its relation to vascular endothelial growth factor (VEGF) expression as an angiogenic and poor prognostic factor. 179 esophageal tissue samples from 69 patients (29 with esophageal cancer and 40 controls) were studied. CNR1 gene mutation (1359 G --> A in codon 453) was detected with PCR, using the MspI restriction enzyme. VEGF was determined by immunoassay. Genotyping in control patients' samples revealed that 24/40 were G/G wild type and 16/40 were G/A; no samples were A/A. Of the 139 tissue samples from the 29 esophageal cancer patients, 15 were G/G homozygous, 85 G/A heterozygous, 11 had an A/A genotype and 28 were without amplification. In the normal tissue adjacent to tumor, some mutations were observed...
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Biomédica, 2004
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Oncology, 2009
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the ce... more The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system. The surgically rejected specimens of human colorectal cancers and paired normal tissues were studied to detect mutations in the CNR1 gene by sequencing method. The results were compared to clinicopathological parameters and correlated with overall survival time. Sixty-three colorectal cancer patients, who underwent surgical excision of colorectal carcinoma, were included in this study. The coding region of the CNR1 gene was studied: a nucleotide change (G-->A) at position 1359 was identified by direct sequencing of PCR. Thirty-eight patients had the G/G genotype (wild type) in tumor areas and 25 patients had G/A heterozygous or A/A homozygous genotype. Univariate analysis revealed 2 independent variables associated with CNR1 gene mutation. The results show that the patients with Dukes stage C and D had a 2.9 times (p = 0.04) and patients that were lymph node positive had 2.8 times (p = 0.05) greater probability of nucleotide change in CNR1 gene. Genotype G/A plus A/A had a shorter overall survival time than G/G wild-type patients (p < 0.05). Indeed nontumor paired colorectal tissues showed nucleotide change. A large number of patients with mutation in the CNR1 gene were observed. These preliminary findings highlight the importance of further studies in the use of cannabinoid analogs as receptor ligands to analyze potential therapeutic effects.
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Journal of Carcinogenesis, 2009
The hypothalamic luteinizing hormone-releasing hormone (LHRH) is well known for its role in the c... more The hypothalamic luteinizing hormone-releasing hormone (LHRH) is well known for its role in the control of pituitary gonadotropin secretion and it has demonstrated a direct antiproliferative effect on some cancer cell lines of LHRH and its synthetic analogs. The study was designed to assess whether administration of the LHRH analog (goserelin) has any effect on the expression of the vascular endothelial growth factor (VEGF) and the epidermal growth factor receptor (EGFR) in rats with N-nitroso-N-methylurea (NMU)-induced-mammary tumors " in vivo". The animals with tumors were assessed after acute or chronic treatment with goserelin, and in all the animals VEGF and EGFR expression was examined both in plasma and tumor homogenates by enzyme immunoassay. The basal plasma values of VEGF were lower in the healthy control group than in rats with NMU-induced tumors ( P = 0.025). Following acute treatment with goserelin, VEGF expression in plasma increased above basal levels after 60 min ( P = 0.05) and dropped during chronic treatment. Likewise, in the tumor homogenate the mean VEGF expression was higher at 60 min post-goserelin administration than the basal levels, although VEGF expression then diminished at 90 min. Plasma EGFR expression was higher in rats with NMU-induced tumors than in healthy controls ( P Conclusions: The results allow us to conclude that goserelin may exert a short-term stimulatory effect on the release of VEGF, as well as a long-term inhibitory effect on VEGF but not EGFR expression.
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Papers by Fernando Bedoya