D. Humphreys

Publication Date: 2011

Publication Name: RNA

Research Interests:
RNA, Humans, microRNAs, HeLa cells, Transfection, and 4 moreProtein isoforms, Protein Biosynthesis, Biochemistry and cell biology, and Gene Expression Regulation

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Publication Date: 2010

Publication Name: Molecular & Cellular Proteomics

Research Interests:
Proteomics, Multidisciplinary, RNA interference, Humans, Mice, and 5 moreAnimals, Phosphorylation, Proteins, microRNAs, and Gene Expression Regulation

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Publication Date: 2012

Publication Name: PLoS ONE

Research Interests:
Thermodynamics, MicroRNA, Multidisciplinary, Next generation sequencing, Mice, and 8 moreAnimals, Heart Development, Small RNA, PLoS one, microRNAs, Genetic variation, Base Sequence, and Genome Mapping

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A flurry of recent studies, carried out primarily in transfected cells or in vitro translation systems, have attempted to reveal the molecular means by which animal microRNAs (miRNAs) attenuate mRNA translation. Despite these intense... more

A flurry of recent studies, carried out primarily in transfected cells or in vitro translation systems, have attempted to reveal the molecular means by which animal microRNAs (miRNAs) attenuate mRNA translation. Despite these intense efforts it has not yet been possible to derive a consensus model for such a mechanism. Here we summarise our own experimental contributions to this topic, which led us to propose that miRNAs control early translation initiation by affecting eukaryotic initiation factor 4E/cap structure and poly(A) tail function, and place them in a current context of this rapidly moving and challenging field.