Papers by Anton A Polyansky
bioRxiv (Cold Spring Harbor Laboratory), Feb 27, 2022
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Nature Communications, Sep 24, 2023
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Acta Crystallographica, Aug 14, 2021
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Fundamental & Clinical Pharmacology, 2004
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Nature Communications, Jan 11, 2023
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Scientific Reports, Nov 15, 2022
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bioRxiv (Cold Spring Harbor Laboratory), Oct 15, 2022
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Nucleic Acids Research, Mar 31, 2022
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Constitutive activation of receptor tyrosine kinases (RTKs) via different mutation has a strong i... more Constitutive activation of receptor tyrosine kinases (RTKs) via different mutation has a strong impact into development of severe human disorders, including cancer. While pathological effect of such mutations can be common on the phenotypical level, mechanistic understanding of their contribution into the receptor activation depends on the exact molecular context. Mutations in transmembrane (TM) domains represent an interesting class of pathological modifications since they can directly affect a signal transduction pathway from the receptor to the kinase domains of RTKs. Here we propose a putative activation scenario of RTK, whereby TM mutations can also promote higher order oligomerization of the receptors that leads to the subsequent ligand-free activation. To illustrate this model with all-atom resolution for a previously characterized oncogenic TM mutation V536E in platelet-derived growth factor receptor alpha (PDGFRA), we use a computational modeling framework including sequenc...
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EMBO Molecular Medicine
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Biophysical Journal, 2019
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ABSTRACTThe brain extracellular matrix (ECM) is enriched in chondroitin sulphate proteoglycans (C... more ABSTRACTThe brain extracellular matrix (ECM) is enriched in chondroitin sulphate proteoglycans (CSPGs) with variable sulphate modifications that intimately participate in brain maturation and function. Very little is known about how the changing biophysical properties of the CSPGs are signalled to neurons. Here, we report Fibrinogen C Domain Containing 1 (FIBCD1), a known chitin-binding receptor of the innate immune system, to be highly expressed in the hippocampus and to specifically bind CSPGs containing 4-O sulphate modification (CS-4S). Cultured Fibcd1 knockout (KO) neurons lack phenotypic and transcriptomic responses to CSPG stimulation. Further, Fibcd1 KO mice exhibit accumulation of CS-4S, likely resulting in deficits of hippocampal-dependent learning tasks and abrogated synaptic remodelling, a phenotype rescued by enzymatic digestion of CSPGs. Likewise, neuronal specific knockdown of a Fibcd1 orthologue in flies results in neuronal morphological changes at the neuromuscular ...
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eLife, Jul 20, 2023
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Computational and Structural Biotechnology Journal
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Biophysical Journal
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… and Bioinformatics of …, 2011
Cell membranes, along with their individual components like membrane-bound proteins, particular l... more Cell membranes, along with their individual components like membrane-bound proteins, particular lipids or lipid bilayer itself, attract a growing attention as very perspective pharmacological targets. According to recent estimations, up to 70% of currently marketed ...
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HASH(0x7fc5f13ca428), 2017
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Science Advances, 2021
Sarcomeric proteins FATZ-1 and α-actinin-2 associate in a tight fuzzy complex, which forms phase-... more Sarcomeric proteins FATZ-1 and α-actinin-2 associate in a tight fuzzy complex, which forms phase-separated condensates.
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Papers by Anton A Polyansky