Papers by Elton Bahtiri, MD, PhD
The interest of several studies of the recent years has been focused on the association between i... more The interest of several studies of the recent years has been focused on the association between increased serum concentrations of homocysteine (Hcy) and reduced bone mineral density and increased risk of bone fractures. Nevertheless, the inconsistencies persist. Although there are several putative mechanisms to link hyperhomocysteinemia (HHcy) with the pathogenesis of osteoporosis, the mechanistic link between HHcy and osteoporosis and osteoporotic fractures is complicated and cannot be explained only through BMD. The objective of this study was to investigate the possible relationship between serum homocysteine and vitamin B12 status and bone mineral density on a group of post-menopausal women. One-hundred-forty postmenopausal women were recruited to enter in this cross-sectional study. Bone mineral density (BMD) of total hip, femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (DEXA) and serum homocysteine, vitamin B12 and parathyroid hormone (PTH) level...
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Journal of Pharmacology and Pharmacotherapeutics, 2012
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Objective: Recent studies revealed conflicting
results regarding relationship between calcium,
ma... more Objective: Recent studies revealed conflicting
results regarding relationship between calcium,
magnesium and iron serum levels and bone mineral
density. This study aimed to investigate correlation
between serum levels of these elements and
bone mineral density in postmenopausal women.
Methods: A total of 140 postmenopausal women
divided into three groups according to lumbar
vertebrae bone mineral density (Total T-score)
were included in the study. Data on subjects’ age,
body mass index (BMI), duration of menopause,
bone mineral density (BMD) in lumbar vertebrae,
femur neck and hip, as well as serum levels of
calcium, magnesium and iron were collected. Dual-
energy X-ray absorptiometry (DXA) was done
to estimate BMD. One-way ANOVA was performed
to compare characteristics of the groups and
Person’s correlation test was performed to test
correlation between variables.
Results: Comparison between groups by oneway
ANOVA showed no significant difference
in elements contents, while Pearson’s correlation
analysis failed to demonstrate statistically significant
correlation between BMD and element contents.
Conclusion: Lack of significant correlation
between serum element contents analyzed in this
study and BMD urges further studies before magnesium
or iron supplements are advised in cases
other than deficiencies.
Bookmarks Related papers MentionsView impact
OBJECTIVE:
The focus of several studies in recent years has been the association between increa... more OBJECTIVE:
The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women.
MATERIALS AND METHODS:
One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study. Bone mineral density (BMD) of total hip, femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (DXA) and serum Hcy, vitamin B12, parathyroid hormone (PTH), total calcium and magnesium levels were determined. In addition, we investigated the relationship of Hcy and vitamin B12 and BMD using a meta-analysis approach.
RESULTS:
Serum Hcy levels were significantly higher in osteoporotic women when compared to other BMD groups, and were inversely related to lumbar spine BMD and femur neck BMD. Body mass index and serum Hcy levels were shown to be significant predictors of BMD at lumbar spine, femur neck and total hip. The performed meta-analysis showed that serum Hcy levels were significantly higher in osteoporotic subjects compared to normal BMD subjects.
CONCLUSION:
This study shows that Hcy status, but not vitamin B12 status, is associated with BMD in this cohort of postmenopausal women. We therefore confirm that high Hcy levels are an independent risk factor for osteoporosis. BMD evaluation in women at post menopause with high Hcy levels may be helpful in advising precautionary measures.
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BACKGROUND AND OBJECTIVE:
Body weight and body mass index (BMI) are considered strong predictor... more BACKGROUND AND OBJECTIVE:
Body weight and body mass index (BMI) are considered strong predictors of osteoporotic fractures, though optimal BMI levels remain unsettled. There are several studies conducted on women about the relationship between BMI and bone mineral density (BMD), and just a few so far on men. Therefore, the objective of current study was to analyze the relationship between weight and BMI and BMD measured in lumbar spine (L1-L4), femur neck and total hip in 64 men from Kosovo.
METHODS:
This cross-sectional study included a population of 64 men divided into three BMI groups. Dual-energy X-ray absorptiometry (DEXA) measurements were done in all the study participants.
RESULTS:
Pearson's correlation analysis showed a significant positive correlation between weight and BMI and BMD in femur neck and in total hip, and a significant negative correlation between age and femur neck BMD. Age-adjusted linear regression analysis showed that weight and BMI had a significant positive association with BMD levels.
CONCLUSION:
Although the results show significant relationship between BMI and BMD, the negative relationship between age and femur neck BMD may serve as guidance to initiate early assessment of the BMD in this region as well as preventive measures of osteoporosis and fractures among ageing men population.
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Bookmarks Related papers MentionsView impact
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Papers by Elton Bahtiri, MD, PhD
results regarding relationship between calcium,
magnesium and iron serum levels and bone mineral
density. This study aimed to investigate correlation
between serum levels of these elements and
bone mineral density in postmenopausal women.
Methods: A total of 140 postmenopausal women
divided into three groups according to lumbar
vertebrae bone mineral density (Total T-score)
were included in the study. Data on subjects’ age,
body mass index (BMI), duration of menopause,
bone mineral density (BMD) in lumbar vertebrae,
femur neck and hip, as well as serum levels of
calcium, magnesium and iron were collected. Dual-
energy X-ray absorptiometry (DXA) was done
to estimate BMD. One-way ANOVA was performed
to compare characteristics of the groups and
Person’s correlation test was performed to test
correlation between variables.
Results: Comparison between groups by oneway
ANOVA showed no significant difference
in elements contents, while Pearson’s correlation
analysis failed to demonstrate statistically significant
correlation between BMD and element contents.
Conclusion: Lack of significant correlation
between serum element contents analyzed in this
study and BMD urges further studies before magnesium
or iron supplements are advised in cases
other than deficiencies.
The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women.
MATERIALS AND METHODS:
One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study. Bone mineral density (BMD) of total hip, femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (DXA) and serum Hcy, vitamin B12, parathyroid hormone (PTH), total calcium and magnesium levels were determined. In addition, we investigated the relationship of Hcy and vitamin B12 and BMD using a meta-analysis approach.
RESULTS:
Serum Hcy levels were significantly higher in osteoporotic women when compared to other BMD groups, and were inversely related to lumbar spine BMD and femur neck BMD. Body mass index and serum Hcy levels were shown to be significant predictors of BMD at lumbar spine, femur neck and total hip. The performed meta-analysis showed that serum Hcy levels were significantly higher in osteoporotic subjects compared to normal BMD subjects.
CONCLUSION:
This study shows that Hcy status, but not vitamin B12 status, is associated with BMD in this cohort of postmenopausal women. We therefore confirm that high Hcy levels are an independent risk factor for osteoporosis. BMD evaluation in women at post menopause with high Hcy levels may be helpful in advising precautionary measures.
Body weight and body mass index (BMI) are considered strong predictors of osteoporotic fractures, though optimal BMI levels remain unsettled. There are several studies conducted on women about the relationship between BMI and bone mineral density (BMD), and just a few so far on men. Therefore, the objective of current study was to analyze the relationship between weight and BMI and BMD measured in lumbar spine (L1-L4), femur neck and total hip in 64 men from Kosovo.
METHODS:
This cross-sectional study included a population of 64 men divided into three BMI groups. Dual-energy X-ray absorptiometry (DEXA) measurements were done in all the study participants.
RESULTS:
Pearson's correlation analysis showed a significant positive correlation between weight and BMI and BMD in femur neck and in total hip, and a significant negative correlation between age and femur neck BMD. Age-adjusted linear regression analysis showed that weight and BMI had a significant positive association with BMD levels.
CONCLUSION:
Although the results show significant relationship between BMI and BMD, the negative relationship between age and femur neck BMD may serve as guidance to initiate early assessment of the BMD in this region as well as preventive measures of osteoporosis and fractures among ageing men population.
results regarding relationship between calcium,
magnesium and iron serum levels and bone mineral
density. This study aimed to investigate correlation
between serum levels of these elements and
bone mineral density in postmenopausal women.
Methods: A total of 140 postmenopausal women
divided into three groups according to lumbar
vertebrae bone mineral density (Total T-score)
were included in the study. Data on subjects’ age,
body mass index (BMI), duration of menopause,
bone mineral density (BMD) in lumbar vertebrae,
femur neck and hip, as well as serum levels of
calcium, magnesium and iron were collected. Dual-
energy X-ray absorptiometry (DXA) was done
to estimate BMD. One-way ANOVA was performed
to compare characteristics of the groups and
Person’s correlation test was performed to test
correlation between variables.
Results: Comparison between groups by oneway
ANOVA showed no significant difference
in elements contents, while Pearson’s correlation
analysis failed to demonstrate statistically significant
correlation between BMD and element contents.
Conclusion: Lack of significant correlation
between serum element contents analyzed in this
study and BMD urges further studies before magnesium
or iron supplements are advised in cases
other than deficiencies.
The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women.
MATERIALS AND METHODS:
One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study. Bone mineral density (BMD) of total hip, femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (DXA) and serum Hcy, vitamin B12, parathyroid hormone (PTH), total calcium and magnesium levels were determined. In addition, we investigated the relationship of Hcy and vitamin B12 and BMD using a meta-analysis approach.
RESULTS:
Serum Hcy levels were significantly higher in osteoporotic women when compared to other BMD groups, and were inversely related to lumbar spine BMD and femur neck BMD. Body mass index and serum Hcy levels were shown to be significant predictors of BMD at lumbar spine, femur neck and total hip. The performed meta-analysis showed that serum Hcy levels were significantly higher in osteoporotic subjects compared to normal BMD subjects.
CONCLUSION:
This study shows that Hcy status, but not vitamin B12 status, is associated with BMD in this cohort of postmenopausal women. We therefore confirm that high Hcy levels are an independent risk factor for osteoporosis. BMD evaluation in women at post menopause with high Hcy levels may be helpful in advising precautionary measures.
Body weight and body mass index (BMI) are considered strong predictors of osteoporotic fractures, though optimal BMI levels remain unsettled. There are several studies conducted on women about the relationship between BMI and bone mineral density (BMD), and just a few so far on men. Therefore, the objective of current study was to analyze the relationship between weight and BMI and BMD measured in lumbar spine (L1-L4), femur neck and total hip in 64 men from Kosovo.
METHODS:
This cross-sectional study included a population of 64 men divided into three BMI groups. Dual-energy X-ray absorptiometry (DEXA) measurements were done in all the study participants.
RESULTS:
Pearson's correlation analysis showed a significant positive correlation between weight and BMI and BMD in femur neck and in total hip, and a significant negative correlation between age and femur neck BMD. Age-adjusted linear regression analysis showed that weight and BMI had a significant positive association with BMD levels.
CONCLUSION:
Although the results show significant relationship between BMI and BMD, the negative relationship between age and femur neck BMD may serve as guidance to initiate early assessment of the BMD in this region as well as preventive measures of osteoporosis and fractures among ageing men population.