Margaret Nordlie
University of Mary, Biology, Faculty Member
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Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to... more
Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies documenting genetic changes associated with myocardial ischemia and infarction as well as those investigating the safety and effectiveness of gene therapy for stimulating angiogenesis, protecting the heart against reperfusion injury, and treating heart failure. Also discussed are future research directions, including the potential use of RNA interference and combined stem cell therapy and gene therapy for the treatment of cardiovascular disease.
Publication Date: 2006
Publication Name: Journal of cardiovascular pharmacology and therapeutics
Research Interests: Genetics, Gene Therapy, Cardiovascular disease, Stem cell Therapy, Stem Cell Transplantation, and 12 moreHeart Failure, RNA interference, Humans, Animals, Peripheral Vascular Disease, Myocardial Infarction, Myocardium, Ischemic Heart Disease, Reperfusion injury, Ventricular Remodeling, Ischemia–reperfusion, and Gene expression profiling
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Molecular Aspects of Ischemic Heart Disease: Ischemia/Reperfusion-Induced Genetic Changes and Potential Applications of Gene and RNA Interference Therapymore
by Margaret Nordlie and Robert Kloner
Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to... more
Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies documenting genetic changes associated with myocardial ischemia and infarction as well as those investigating the safety and effectiveness
Publication Date: 2000
Research Interests: Genetics, Gene Therapy, Cardiovascular disease, Stem cell Therapy, Stem Cell Transplantation, and 12 moreHeart Failure, RNA interference, Humans, Animals, Peripheral Vascular Disease, Myocardial Infarction, Myocardium, Ischemic Heart Disease, Reperfusion injury, Ventricular Remodeling, Ischemia–reperfusion, and Gene expression profiling
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by Margaret Nordlie and Robert Kloner
Publication Date: 2005
Publication Name: Journal of Molecular and Cellular Cardiology
Research Interests: Genetics, Gene Therapy, Cardiovascular disease, CAD, NO, and 22 moreHumans, United States, ALP, Apoe, Economic Impact, CVD, MTHFR, Lipid metabolism, Risk factors, Lipoprotein(a), apoB, Heart Disease, Enzyme, IL, Coronary heart disease, Risk Factors, Ischemic Heart Disease, Coronary Artery Disease, RFLP, HDL, VLDL, and LDLR
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In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmiasmore
by Robert Kloner and Margaret Nordlie
Exposure to ultrafine particles (UFPs) by inhalation increases the number and severity of cardiac events. The specific mechanism(s), of action are unknown. This study was designed to examine whether UFPs could exert a direct effect on the... more
Exposure to ultrafine particles (UFPs) by inhalation increases the number and severity of cardiac events. The specific mechanism(s), of action are unknown. This study was designed to examine whether UFPs could exert a direct effect on the cardiovascular system without dependence upon lung-mediated responses. The direct effects of UFPs were determined in normal rats (infused intravenously with UFPs), and in