Novel strategies are required to manufacture customized oral solid dosage forms for personalized ... more Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs.
Personalized medicine aims to tailor drug combination and dosage manufacturing to the specific ne... more Personalized medicine aims to tailor drug combination and dosage manufacturing to the specific needs of a patient by taking into consideration its genetic profile, phenotypic response, and pathophysiology. New technologies are needed to enable the rapid manufacturing of custom pharmaceutical tablets in a scalable manner, while meeting quality assurance regulatory standards. 3D Pharming, the use of 3D Printing to directly fabricate personalized pharmaceutical tablets, is under intense development by many investigators due to its unprecedented control for: 1) stability of multiple drugs within a pill; 2) precise dose of each drug; and 3) release kinetics of each component by incorporating designed structures that can modulate dissolution and diffusion profiles. Additionally, it has the potential to scale in order to meet the economics and quality that the pharmaceutical industry demands. This article reviews the manufacture of pharmaceutical tablets through powder bed inkjet 3D printing and fused deposition modelling, the two 3D printing techniques with the greatest progress towards personalized pharmaceutical tablets. The engineering of pills through these two methods, featuring varied dissolution profiles, chemical complexions, dosages, and multiple drugs incorporation, is thoroughly discussed.
Novel strategies are required to manufacture customized oral solid dosage forms for personalized ... more Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs.
Personalized medicine aims to tailor drug combination and dosage manufacturing to the specific ne... more Personalized medicine aims to tailor drug combination and dosage manufacturing to the specific needs of a patient by taking into consideration its genetic profile, phenotypic response, and pathophysiology. New technologies are needed to enable the rapid manufacturing of custom pharmaceutical tablets in a scalable manner, while meeting quality assurance regulatory standards. 3D Pharming, the use of 3D Printing to directly fabricate personalized pharmaceutical tablets, is under intense development by many investigators due to its unprecedented control for: 1) stability of multiple drugs within a pill; 2) precise dose of each drug; and 3) release kinetics of each component by incorporating designed structures that can modulate dissolution and diffusion profiles. Additionally, it has the potential to scale in order to meet the economics and quality that the pharmaceutical industry demands. This article reviews the manufacture of pharmaceutical tablets through powder bed inkjet 3D printing and fused deposition modelling, the two 3D printing techniques with the greatest progress towards personalized pharmaceutical tablets. The engineering of pills through these two methods, featuring varied dissolution profiles, chemical complexions, dosages, and multiple drugs incorporation, is thoroughly discussed.
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