SB-408,124

SB-408,124
IUPAC ime
	N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Identifikatori
CAS broj	288150-92-5
Hemijski podaci
Formula	C19H18F2N4O
Molarna masa	356.368 g/mol
	SMILES c3cc(N(C)C)ccc3NC(=O)Nc1cc(C)nc2c1cc(F)cc2F; ;

SB-408,124 je lek koji je ne-peptidni selektivni antagonist oreksinskog receptora, tipa OX₁. On je oko 70 puta selektivniji za OX₁ nego OX₂ receptor, ima poboljšanu oralnu biodostupnost u poređenju sa starijim OX₁ antagonistom SB-334,867. On se koristi u naučnim istraživanjima funkcije oreksinergičkih neurona u telu.^[1]^[2]

Literatura

^ Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). „Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor”. British journal of pharmacology. 141 (2): 340—6. PMC 1574197 . PMID 14691055. doi:10.1038/sj.bjp.0705610.
^ Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH; Chen, GD (2008). „Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit”. American journal of physiology. Endocrinology and metabolism. 295 (1): E117—29. PMID 18477704. doi:10.1152/ajpendo.90243.2008.

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[1] Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). „Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor”. British journal of pharmacology. 141 (2): 340—6. PMC 1574197 . PMID 14691055. doi:10.1038/sj.bjp.0705610.

[2] Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH; Chen, GD (2008). „Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit”. American journal of physiology. Endocrinology and metabolism. 295 (1): E117—29. PMID 18477704. doi:10.1152/ajpendo.90243.2008.

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