LPAR1

Receptor lizofosfatidne kiseline 1
Receptor lizofosfatidne kiseline 1
Identifikatori
Simboli	LPAR1; EDG2; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1
Vanjski ID	OMIM: 602282 MGI: 108429 HomoloGene: 1072 IUPHAR: LPA1 GeneCards: LPAR1 Gene
Ontologija gena
Molekularna funkcija	• vezivanje G-protein alfa podjedinice; • aktivnost G-protein spregnutog receptora; • proteinsko vezivanje; • fosfolipidno vezivanje;
Celularna komponenta	• citoplazma; • ćelijska membrana; • integralno sa ćelijskom membranom; • ćelijska površina;
Biološki proces	• activacija MAPK aktivnosti; • signalni put G-protein spregnutog receptora; • aktivacija fosfolipaze C; • povišenje koncentracije citozolnih jona kalcijuma;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	1902
Ensembl	ENSG00000198121
UniProt	Q92633
RefSeq (mRNA)	NM_001401.3
RefSeq (protein)	NP_001392.2
Lokacija (UCSC)	Chr 9:; 113.64 - 113.8 Mb
PubMed pretraga	[1]

Receptor lizofosfatidne kiseline 1 (LPA₁) je protein koji je kod ljudi kodiran LPAR1 genom.^[1]^[2]^[3] LPA₁ je G protein spregnuti receptor za koji se vezuje lipidni signalni molekul lizofosfatidna kiselina (LPA).^[4]

Funkcija

Integralni membranski protein kodiran ovim genom pripada grupi EDG receptora. Ti receptori su članovi familije G protein spregnutih receptora. EDG receptori posreduju različite bioločkie funkcije, uključujući proliferaciju, agregaciju trombocita, kontrakcije glatkih mišića, inhibiciju diferencijaciju neuroblastomnih ćelija, hemotaksu, i invaziju tumornih ćelija. Alternativno splajsovanje ovog gena je uočeno i dve transkriptne varijante su opisane. One kodiraju identične proteine.^[1]

Reference

^ ^а ^б „Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1”.
^ Hecht JH, Weiner JA, Post SR, Chun J (1996). „Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex”. J. Cell Biol. 135 (4): 1071—83. PMC 2133395 . PMID 8922387. doi:10.1083/jcb.135.4.1071.
^ An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997). „Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid”. Biochem. Biophys. Res. Commun. 231 (3): 619—22. PMID 9070858. doi:10.1006/bbrc.1997.6150.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology. 50 (1): 157—186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753.

Literatura

An S, Goetzl EJ, Lee H (1999). „Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.”. J. Cell. Biochem. Suppl. 30-31: 147—57. PMID 9893266.
Contos JJ, Ishii I, Chun J (2001). „Lysophosphatidic acid receptors.”. Mol. Pharmacol. 58 (6): 1188—96. PMID 11093753.
Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). „Lysophosphatidic acid: G-protein signalling and cellular responses.”. Curr. Opin. Cell Biol. 9 (2): 168—73. PMID 9069262. doi:10.1016/S0955-0674(97)80059-2.
Fukushima N, Kimura Y, Chun J (1998). „A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.”. Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151—6. PMC 27607 . PMID 9600933. doi:10.1073/pnas.95.11.6151.
An S, Bleu T, Zheng Y, Goetzl EJ (1998). „Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.”. Mol. Pharmacol. 54 (5): 881—8. PMID 9804623.
Cervera, P.; M, Tirard; Barron, S.; et al. (2002). „Immunohistological localization of the myelinating cell-specific receptor LP(A1).”. Glia. 38 (2): 126—36. PMID 11948806. doi:10.1002/glia.10054.
Hama, K.; K, Bandoh; Kakehi, Y.; et al. (2002). „Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.”. FEBS Lett. 523 (1-3): 187—92. PMID 12123830. doi:10.1016/S0014-5793(02)02976-9.
Van Leeuwen FN; Olivo, C.; S, Grivell; et al. (2003). „Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.”. J. Biol. Chem. 278 (1): 400—6. PMID 12393875. doi:10.1074/jbc.M210151200.
Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). „Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.”. J. Cell. Sci. 116 (Pt 10): 1969—80. PMID 12668728. doi:10.1242/jcs.00397.
Shida, D.; J, Kitayama; Yamaguchi, H.; et al. (2003). „Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.”. Cancer Res. 63 (7): 1706—11. PMID 12670925.
Matsuda, A.; Y, Suzuki; Honda, G.; et al. (2003). „Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.”. Oncogene. 22 (21): 3307—18. PMID 12761501. doi:10.1038/sj.onc.1206406.
Xu J, Lai YJ, Lin WC, Lin FT (2004). „TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.”. J. Biol. Chem. 279 (11): 10459—68. PMID 14688263. doi:10.1074/jbc.M311891200.
Komuro, Y.; T, Watanabe; Kitayama, J.; et al. (2004). „The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.”. Hepatogastroenterology. 50 (54): 1770—3. PMID 14696401.
Ota, T.; Y, Suzuki; Nishikawa, T.; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Kaneider, N. C.; Lindner, J.; C, Feistritzer; et al. (2005). „The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.”. FASEB J. 18 (11): 1309—11. PMID 15208267. doi:10.1096/fj.03-1050fje.

Vidi još

Lizofosfolipidni receptor

Spoljašnje veze

„Lysophospholipid Receptors: LPA₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
Lysophospholipid+receptors на US National Library of Medicine Medical Subject Headings (MeSH)

[entrez-1] а ^б „Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1”.

[pmid8922387-2] Hecht JH, Weiner JA, Post SR, Chun J (1996). „Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex”. J. Cell Biol. 135 (4): 1071—83. PMC 2133395 . PMID 8922387. doi:10.1083/jcb.135.4.1071.

[pmid9070858-3] An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997). „Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid”. Biochem. Biophys. Res. Commun. 231 (3): 619—22. PMID 9070858. doi:10.1006/bbrc.1997.6150.

[Choi_2010-4] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology. 50 (1): 157—186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753.

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