Enprostil

Enprostil
IUPAC ime
	Metil 7-[(1S,2S,3S)- 3-hidroksi-2-[(S,E)-3-hidroksi-4-fenoksibut-1-enil]-5-oksociklopentil]hepta-4,5-dienoat
Klinički podaci
Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	73121-56-9
ATC kod	A02BB02 (WHO)
PubChem	CID 51744
UNII	J4IP5Z9DAU
KEGG	D01891
Hemijski podaci
Formula	C23H28O6
Molarna masa	400,46 g/mol

Enprostil je sintetički prostaglandin koji je sličan sa dinoprostonom. Enprostil je veoma potentan inhibitor sekrecije želudačne HCl.^[1]

Reference

^ Roszkowski, AP; Garay, GL; Baker, S; Schuler, M; Carter, H (1986). „Gastric antisecretory and antiulcer properties of enprostil, (+/-)-11 alpha, 15 alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-9-oxoprosta- 4,5,13(t)-trienoic acid methyl ester”. The Journal of Pharmacology and Experimental Therapeutics. 239 (2): 382—9. PMID 3095537.

Toshina, K.; Hirata, I.; Maemura, K.; Sasaki, S.; Murano, M.; Nitta, M.; Yamauchi, H.; Nishikawa, T.; Hamamoto, N. (2000). „Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines”. Scandinavian Journal of Immunology. 52 (6): 570—5. PMID 11119262. doi:10.1046/j.1365-3083.2000.00815.x.
Tari, Akira; Hamada, Masanori; Kamiyasu, Toshiki; Sumii, Koji; Haruma, Ken; Inoue, Masaki; Kishimoto, Shinya; Kajiyama, Goro; Walsh, John H. (1997). „Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients”. Digestive Diseases and Sciences. 42 (8): 1741—6. PMID 9286243. doi:10.1023/A:1018825902055.
Ching, C. K.; Lam, S. K. (1995). „A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease”. Journal of Gastroenterology. 30 (5): 607—14. PMID 8574332. doi:10.1007/BF02367786.

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