Cefalotin

Cefalotin
IUPAC ime
	(6R,7R)-3-[(acetoksi)metil]-8-okso-7-[(2-tienilacetil)amino]-5-tia-1-azabiciklo[4.2.0]okt-2-en-2-karboksilna kiselina
Klinički podaci
Drugs.com	Internacionalno ime leka
MedlinePlus	a682860
Kategorija trudnoće	AU: A ; ;
Način primene	IV
Pravni status
Pravni status	AU: S4 (Prescription only) ; UK: POM (Samo na recepat) ;
Farmakokinetički podaci
Bioraspoloživost	n/a
Vezivanje proteina	65 to 80%
Metabolizam	Hepatic
Poluvreme eliminacije	30 minuta do 1 data
Izlučivanje	Renalno
Identifikatori
CAS broj	153-61-7
ATC kod	J01DB03 (WHO)
PubChem	CID 6024
DrugBank	DB00456
ChemSpider	5802
UNII	R72LW146E6
KEGG	D07635
ChEBI	CHEBI:124991
ChEMBL	CHEMBL617
Hemijski podaci
Formula	C16H16N2O6S2
Molarna masa	396,44 g/mol
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cc3sccc3)COC(=O)C)C(=O)O; ;
	InChI InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1 ; Key:XIURVHNZVLADCM-IUODEOHRSA-N ;

Cefalotin (INN) je cefalosporinski antibiotik prve generacije. On je bio privi cefalosporin koji je plasiran na trižište (1964). On je i dalje u širokoj upotrebi. Cefalotin se intravenoznol administerira. Njegov antimikrobni spektar je sličan cefazolinu i oralnom agensu cefaleksinu. Cefalotin natrijum je u prodaji pod imenom Keflin.^[1]^[2]^[3]^[4]

Reference

^ Singh P, Dimitriou V, Mahajan RP, Crossley AW: Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering. Br J Anaesth. 1993 Nov;71(5):685-8. PMID 8251281
^ Yost CS: A new look at the respiratory stimulant doxapram. CNS Drug Rev. 2006 Fall-Winter;12(3-4):236-49. PMID 17227289
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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[1] Singh P, Dimitriou V, Mahajan RP, Crossley AW: Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering. Br J Anaesth. 1993 Nov;71(5):685-8. PMID 8251281

[2] Yost CS: A new look at the respiratory stimulant doxapram. CNS Drug Rev. 2006 Fall-Winter;12(3-4):236-49. PMID 17227289

[3] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[4] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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