- Southampton, Southampton, United Kingdom
- University of Warwick, Warwick Evidence, Department Memberadd
- Jill is co-founder and partner of Effective Evidence and a Visiting Fellow at the University of Southampton. With alm... moreJill is co-founder and partner of Effective Evidence and a Visiting Fellow at the University of Southampton. With almost 20 years’ experience of conducting evidence syntheses, Jill is proficient in all aspects of the design, project management, execution and reporting of systematic reviews and meta-analyses.edit
Research Interests:
Research Interests:
... Birmingham Edgbaston Birmingham B15 2TT UK Authors Janine Dretzke 1 Jeff Round 2 Martin Connock 1 Sandy Tubeuf 2 Mary Pennant 1 Anne Fry-Smith 1 Claire Hulme 2 Chris McCabe 2 Catherine Meads 1 1 Unit of Public Health ...
Research Interests:
Research Interests: British, Treatment Outcome, Visual acuity, Macular Degeneration, Humans, and 9 moreMonoclonal Antibodies, Systematic review, Age related macular degeneration, Clinical Sciences, Optometry and Ophthalmology, Public health systems and services research, Disease Progression, Choroidal Neovascularization Industry, and Randomized Controlled Trials as Topic
Aims The properties of rapid-acting insulin analogues are thought to be particularly appropriate for use in continuous subcutaneous insulin infusion (CSII) or insulin pump therapy. We conducted a systematic review and meta-analysis of... more
Aims The properties of rapid-acting insulin analogues are thought to be particularly appropriate for use in continuous subcutaneous insulin infusion (CSII) or insulin pump therapy. We conducted a systematic review and meta-analysis of trials comparing rapid-acting insulin analogues with soluble insulin in CSII.Methods The following databases were searched (last search June 2002): MEDLINE 1985–2002; Embase 1980–2002; PubMed internet version, records added June 2001 to June 2002; Science Citation Index 1990–2002; BIOSIS 1999–2002; Web of Science Proceedings 1990–2002; and the Cochrane Library, including DARE and the HTA databases. Randomized controlled trials and crossover studies with at least 10 weeks on each treatment were included. Data extraction and quality assessment were undertaken by one reviewer and checked by a second. A meta-analysis was undertaken using a random effects model.Results A significant improvement of 0.26% (95% confidence interval −0.47, −0.06%) in glycated haemoglobin was demonstrated with lispro. Some studies reported fewer hypoglycaemic episodes with analogue insulin but this varied according to the definitions used. No differences in insulin dosage or weight were seen. Two studies reported patient preference, with analogues preferred in both. The extra cost per annum ranges from £72 (at 40 units per day) to £150 (at 84 units per day).Conclusions Insulin analogues result in a modest but significant reduction in HbA1c compared with soluble insulin when used in CSII, and are preferred by patients.
Research Interests:
Research Interests: Information Systems, Education, Obesity, Clinical Trial, Quality of life, and 16 moreTreatment Outcome, Library and Information Studies, Humans, Weight Loss, Cost effectiveness, Systematic review, Great Britain, Body mass index (BMI), Public health systems and services research, Cost Benefit Analysis, Morbid Obesity, Economic evaluation, Gastric Bypass, Outcome Assessment, Randomized Controlled Trials as Topic, and Review literature
Research Interests: Information Systems, Evidence Based Medicine, Health Care, Quality of life, Survival Analysis, and 21 moreTreatment Outcome, Applied Economics, Heart Failure, Library and Information Studies, Humans, Left Ventricular Assist Device, Cost effectiveness, Left Ventricular Dysfunction, Systematic review, Waiting lists, Great Britain, Quality adjusted life years, Public health systems and services research, Cost Benefit Analysis, Economic evaluation, Heart Transplantation, Continuous Flow Heart Assist Devices, Heart Ventricles, Cohort Studies, Self-help devices, and Randomized Controlled Trials as Topic
Research Interests:
Research Interests: Information Systems, Treatment Outcome, Health Technology, Adolescent, Library and Information Studies, and 14 moreHumans, Child, Infant, Cost effectiveness, Prevalence, Great Britain, Topical Drug Administration, Adult, Public health systems and services research, Cost Benefit Analysis, Atopic Dermatitis, Severity of Illness Index, Randomized Controlled Trials as Topic, and Child preschool
Technology assessment report commissioned by the HTA Programme on behalf of The National Institute for Clinical Excellence Clinical and cost-effectiveness of once daily versus more frequent use of same potency topical corticosteroids for atopic eczema: a systematic review and economic evaluationmore