Rifapentin

Rifapentin
(IUPAC) ime
	(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z,26E)-26[(4-cyclopentylpiperazin-1-yl)amino]methylidene2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27-trioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29)-heptaen-13-yl acetate
Klinički podaci
Identifikatori
CAS broj	61379-65-5
ATC kod	J04AB05
PubChem	5462354
DrugBank	APRD01217
Hemijski podaci
Formula	C47H64N4O12
Mol. masa	877.031 g/mol
InChI
	InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1 ; Key: WDZCUPBHRAEYDL-GZAUEHORSA-N
Sinonimi	3{[(4-cyclopentyl-1-piperazinyl)imino]methyl}rifamycin
Farmakokinetički podaci
Bioraspoloživost	povećava se kad je administriran sa hranom
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Rifapentin, engl. Rifapentine (INN, prodaje kompanija Sanofi-Aventis pod imenom Priftin. Ovaj lek je antibiotik koji se koristi u lečenju tuberkoloze.^[3]

Istorija

Rifapentin je sintetisan prvi put 1965 godine u kompaniji koja proizvela rifampin (Lepetit Pharmaceuticals). Ovaj lek je FDA odobrila juna juna 1998 godine.

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Rosenthal IM, Zhang M, Williams KN, et al. (December 2007). „Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model”. PLoS Medicine 4 (12): e344. DOI:10.1371/journal.pmed.0040344. PMC 2140085. PMID 18092886.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Rosenthal IM, Zhang M, Williams KN, et al. (December 2007). „Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model”. PLoS Medicine 4 (12): e344. DOI:10.1371/journal.pmed.0040344. PMC 2140085. PMID 18092886.

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