5,10-Metilentetrahidrofolat

5,10-Metilentetrahidrofolat
	N-[4-(3-amino-1-okso-1,4,5,6,6a,7-heksahidroimidazo[1,5-f]pteridin-8(9H)-il)benzoil]-L-glutaminska kiselina
Drugi nazivi	5,10-CH2-THF,; MTHF
Identifikacija
CAS registarski broj	3432-99-3
PubChem	108194
ChemSpider	97272
MeSH	5,10-methylenetetrahydrofolate
ChEBI	20502
ChEMBL	CHEMBL117348
Jmol-3D slike	Slika 1
SMILES
	O=C(O)[C@@H](NC(=O)c1ccc(cc1)N4CC3N(C=2C(=O)/N=C(/N)NC=2NC3)C4)CCC(=O)O
InChI
	InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1 ; Kod: QYNUQALWYRSVHF-ABLWVSNPSA-N InChI=1/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1; Kod: QYNUQALWYRSVHF-ABLWVSNPBB
Svojstva
Molekulska formula	C20H23N7O6
Molarna masa	457,44 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

5,10-Metilentetrahidrofolat (5,10-CH₂-THF) je supstrat koji koristi enzim metilentetrahidrofolat reduktaza (MTHFR)^[5]^[6] da formira 5-metiltetrahidrofolat (5-MTHF, ili levomefolnu kiselinu).

5,10-CH₂-THF se takođe koristi kao koenzim u biosintezi timidina. Specifičnije on je C1-donor u reakcijama koje katalizuje timidilat sintaza i timidilat sintaza (FAD). On deluje kao koenzim i u sintezi serina iz glicina posredstvom enzima serin hidroksimetil transferaza.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Entrez Gene: MTHFR methylenetetrahydrofolate reductase (NAD(P)H)”.
↑ Födinger M, Hörl WH, Sunder-Plassmann G (2000). „Molecular biology of 5,10-methylenetetrahydrofolate reductase.”. J Nephrol 13 (1): 20–33. PMID 10720211.

Povezano

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[entrez-5] „Entrez Gene: MTHFR methylenetetrahydrofolate reductase (NAD(P)H)”.

[pmid10720211-6] Födinger M, Hörl WH, Sunder-Plassmann G (2000). „Molecular biology of 5,10-methylenetetrahydrofolate reductase.”. J Nephrol 13 (1): 20–33. PMID 10720211.

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