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Mebendazol
(IUPAC ) ime
metil N-(6-benzoil-1H-1,3-benzodiazol-2-il)karbamat
Klinički podaci
Robne marke
Bantenol, Besantin, Equivurm Plus, Lomper
AHFS/Drugs.com
Monografija
Identifikatori
CAS broj
31431-39-7
ATC kod
P02 CA01
PubChem [ 1] [ 2] 4030
DrugBank
DB00643
ChemSpider [ 3] 3890
ChEMBL [ 4] CHEMBL6704 Y
Hemijski podaci
Formula
C 16 H 13 N 3 O 3
Mol. masa
295.2927
SMILES
eMolekuli PubHem
InChI InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21) Y
Fizički podaci
Tačka topljenja
288.5 °C (551 °F)
Farmakokinetički podaci
Poluvreme eliminacije
2,5 - 5,5 sati
Izlučivanje
Urinom, fekalno
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
Način primene
Oralno
Mebendazol je benzimidazol koji deluje putem ometanja metabolizma ugljenih hidrata i inhibiranja polimerizacije mikrotubula .[ 5] [ 6]
Reference
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682 . ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412 .
