Duodenal neuroendocrine tumours (D-NETS) are rare tumours. The management of D-NETs is complex du... more Duodenal neuroendocrine tumours (D-NETS) are rare tumours. The management of D-NETs is complex due to the lack of understanding of the natural course of the disease. We present a single centre experience in the surgical management of these tumours with long-term follow up
41 retrospective observational studies were identified of 792 obese and super obese patients trea... more 41 retrospective observational studies were identified of 792 obese and super obese patients treated with endoscopic stents for bariatric surgery complications including leaks (n = 770) and strictures (n = 22) post-Roux en Y gastric bypass (n = 228) and sleeve gastrectomy (n = 534). The main outcomes of the studies were the percentage success of stent therapy and percentage stent migration. Stents included self-expanding metal stents (SEMS), including partially covered self-expanding metal stents (PcSEMS) and fully covered self-expanding metal stents (FcSEMS). Several SEMS used were specifically designed for bariatric complications, being larger in diameter to reduce migration. The pooled percentage success for all patients (SG and RYGB) was 80.81% with stent migration occurring in 24.67% in all groups. The pooled percentage success for the RYGB group was 80.28% and in the LSG group was 85.86% with percentage migration occurring in 20.65% and 23.82% respectfully.
The permeability of the intestinal barrier is altered in a multitude of gastrointestinal conditio... more The permeability of the intestinal barrier is altered in a multitude of gastrointestinal conditions such as Crohn’s and coeliac disease. However, the clinical utility of gut permeability is currently limited due to a lack of reliable diagnostic tests. To address this issue, we report a novel technique for rapid, non-invasive measurement of gut permeability based on transcutaneous (‘through-the-skin’) fluorescence spectroscopy. In this approach, participants drink an oral dose of a fluorescent dye (fluorescein) and a fibre-optic fluorescence spectrometer is attached to the finger to detect permeation of the dye from the gut into the blood stream in a non-invasive manner. To validate this technique, clinical trial measurements were performed in 11 healthy participants. First, after 6 h of fasting, participants ingested 500 mg of fluorescein dissolved in 100 ml of water and fluorescence measurements were recorded at the fingertip over the following 3 h. All participants were invited ba...
BMJ Careers has been tracking a cohort of doctors since their first day on the job. This week the... more BMJ Careers has been tracking a cohort of doctors since their first day on the job. This week the six doctors report on their first month as specialty trainees
Last August, six medical graduates wrote an account for BMJ Careers about their first day as doct... more Last August, six medical graduates wrote an account for BMJ Careers about their first day as doctors. One year on they reflect on what they wrote and how their perceptions have changed over the first year
Over the past 18 months BMJ Careers has been following a group of new doctors through their train... more Over the past 18 months BMJ Careers has been following a group of new doctors through their training. This week we hear about their experiences of applying for specialty training posts
Duodenal neuroendocrine tumours (D-NETS) are rare tumours. The management of D-NETs is complex du... more Duodenal neuroendocrine tumours (D-NETS) are rare tumours. The management of D-NETs is complex due to the lack of understanding of the natural course of the disease. We present a single centre experience in the surgical management of these tumours with long-term follow up
41 retrospective observational studies were identified of 792 obese and super obese patients trea... more 41 retrospective observational studies were identified of 792 obese and super obese patients treated with endoscopic stents for bariatric surgery complications including leaks (n = 770) and strictures (n = 22) post-Roux en Y gastric bypass (n = 228) and sleeve gastrectomy (n = 534). The main outcomes of the studies were the percentage success of stent therapy and percentage stent migration. Stents included self-expanding metal stents (SEMS), including partially covered self-expanding metal stents (PcSEMS) and fully covered self-expanding metal stents (FcSEMS). Several SEMS used were specifically designed for bariatric complications, being larger in diameter to reduce migration. The pooled percentage success for all patients (SG and RYGB) was 80.81% with stent migration occurring in 24.67% in all groups. The pooled percentage success for the RYGB group was 80.28% and in the LSG group was 85.86% with percentage migration occurring in 20.65% and 23.82% respectfully.
The permeability of the intestinal barrier is altered in a multitude of gastrointestinal conditio... more The permeability of the intestinal barrier is altered in a multitude of gastrointestinal conditions such as Crohn’s and coeliac disease. However, the clinical utility of gut permeability is currently limited due to a lack of reliable diagnostic tests. To address this issue, we report a novel technique for rapid, non-invasive measurement of gut permeability based on transcutaneous (‘through-the-skin’) fluorescence spectroscopy. In this approach, participants drink an oral dose of a fluorescent dye (fluorescein) and a fibre-optic fluorescence spectrometer is attached to the finger to detect permeation of the dye from the gut into the blood stream in a non-invasive manner. To validate this technique, clinical trial measurements were performed in 11 healthy participants. First, after 6 h of fasting, participants ingested 500 mg of fluorescein dissolved in 100 ml of water and fluorescence measurements were recorded at the fingertip over the following 3 h. All participants were invited ba...
BMJ Careers has been tracking a cohort of doctors since their first day on the job. This week the... more BMJ Careers has been tracking a cohort of doctors since their first day on the job. This week the six doctors report on their first month as specialty trainees
Last August, six medical graduates wrote an account for BMJ Careers about their first day as doct... more Last August, six medical graduates wrote an account for BMJ Careers about their first day as doctors. One year on they reflect on what they wrote and how their perceptions have changed over the first year
Over the past 18 months BMJ Careers has been following a group of new doctors through their train... more Over the past 18 months BMJ Careers has been following a group of new doctors through their training. This week we hear about their experiences of applying for specialty training posts
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