Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disease with widely variable
phenotypes extending from simple steatosis, through nonalcoholic steatohepatitis (NASH) to
cirrhosis and hepatocellular carcinoma. Inevitably, this reflects the interplay of well-
recognized environmental factors and disease associations such as obesity and insulin
resistance with host genetic factors, which are polygenic or complex in nature. Most of the
observed phenotypic variability will probably be explained by variations in single nucleotide …