Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

…, P Guo, J Wu, F Meng, S Shi, E Participants… - Nature …, 2022 - nature.com
… To test such effects and to potentially discover unknown ones, we challenged Eterna
participants to generate a large and diverse set of RNA molecules featuring designed secondary …

Theoretical basis for stabilizing messenger RNA through secondary structure design

…, PS Huang, E Participants… - Nucleic acids …, 2021 - academic.oup.com
… and crowdsourcing through the OpenVaccine challenge on the Eterna platform. We find that
rational design on Eterna and the more sophisticated algorithms lead to constructs with low …

RNA design rules from a massive open laboratory

…, R Das, EteRNA Participants - Proceedings of the …, 2014 - National Acad Sciences
… We, therefore, sought to evaluate the rules independently from EteRNA participants through
… phase II, nine unique targets challenged EteRNA participants, the EteRNABot method, and …

Minimization of the E. coli ribosome, aided and optimized by community science

…, M Palo, J Townley, KB Hsu, E Participants… - Nucleic Acids …, 2024 - academic.oup.com
The ribosome is a ribonucleoprotein complex found in all domains of life. Its role is to
catalyze protein synthesis, the messenger RNA (mRNA)-templated formation of amide bonds …

Deep learning models for predicting RNA degradation via dual crowdsourcing

…, K Amer, M Fares, Eterna Participants… - Nature Machine …, 2022 - nature.com
… We asked participants on the Eterna platform to submit RNA designs using a web-browser
design window (Fig. 1c), which resulted in a diversity of sequences and structures (Fig. 1d). …

EternaBrain: Automated RNA design through move sets and strategies from an Internet-scale RNA videogame

…, F Portela, Eterna participants… - PLoS computational …, 2019 - journals.plos.org
… The Eterna project has crowdsourced RNA design to human … Here, we demonstrate that
Eterna participants’ moves and … 12 of the most-played Eterna puzzles as well as an eternamoves-…

RNA secondary structure packages evaluated and improved by high-throughput experiments

…, J Lee, A Treuille, A Becka, Eterna Participants… - Nature …, 2022 - nature.com
… The community of Eterna participants collectively developed … serial killer 1’, while other
participant projects focused more on better … heatmap of SHAPE data for Eterna-player-designed …

[HTML][HTML] Compact RNA sensors for increasingly complex functions of multiple inputs

…, JJ Nicol, HK Wayment-Steele, M Gotrik, E Participants… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Designing single molecules that compute general functions of input molecular partners
represents a major unsolved challenge in molecular design. Here, we demonstrate that high-…

Crowdsourced RNA design discovers diverse, reversible, efficient, self-contained molecular switches

…, Eterna Participants… - Proceedings of the …, 2022 - National Acad Sciences
Internet-based scientific communities promise a means to apply distributed, diverse human
intelligence toward previously intractable scientific problems. However, current …

Community science designed ribosomes with beneficial phenotypes

…, E Fisker, J Townley, Eterna Participants… - Nature …, 2023 - nature.com
… We aimed to explore the use of the Eterna platform to … on the Eterna platform for the
ribosome’s 16S and 23S rRNAs using a DBTL framework (Fig. 1a). In the Design phase, the Eterna