CD164

CD164
Identificadores
Nomes alternativos	CD164, proteína do núcleo de sialomucina 24, Grupo de diferenciação 164
IDs externos	OMIM: 603356 HomoloGene: 38129 GeneCards: CD164
Doenças Geneticamente Relacionadas
	autosomal dominant nonsyndromic deafness 66
Ontologia genética
Função molecular	• GO:0001948, GO:0016582 ligação a proteínas plasmáticas;
Componente celular	• integral component of membrane; • extracellular region; • lysosomal membrane; • endossoma; • membrana plasmática; • lisossoma; • integral component of plasma membrane; • endosome membrane; • membrane; • GO:0016023 cytoplasmic vesicle;
Processo biológico	• multicellular organism development; • negative regulation of cell adhesion; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • Adesão celular; • muscle organ development; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 resposta imunitária; • GO:0072468 transdução de sinal; • negative regulation of cell population proliferation; • hematopoiese;
	Sources:Amigo / QuickGO
Ortólogos
	8763
	n/a
	ENSG00000135535
	n/a
	Q04900
	n/a
NM_006016; NM_001142401; NM_001142402; NM_001142403; NM_001142404;
	NM_001346500
	n/a
NP_001135873; NP_001135874; NP_001135875; NP_001135876; NP_001333429;
	NP_006007
	n/a
	Wikidata
Ver/Editar Humano

A proteína do núcleo de sialomucina 24 também conhecida como CD164 (Grupo de diferenciação 164) é uma proteína que em humanos é codificada pelo gene CD164.^[3]^[4] O CD164 funciona como uma molécula de adesão celular.^[3]

Referências

↑ «Doenças geneticamente associadas a CD164 ver/editar referências no wikidata»
↑ «Human PubMed Reference:»
↑ ^a ^b Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (Agosto de 1998). «CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21». Blood. 92 (3): 849–66. PMID 9680353
↑ Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (Outubro de 1998). «The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis». Blood. 92 (8): 2613–28. PMID 9763543

Leitura adicional

*Zannettino AC (2001). «CD164.». J. Biol. Regul. Homeost. Agents. 15 (4): 394–6. PMID 11862985*Masuzawa Y, Miyauchi T, Hamanoue M, et al. (1992). «A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression.». J. Biochem. 112 (5): 609–15. PMID 1478919. doi:10.1093/oxfordjournals.jbchem.a123948*Zhou GQ, Zhang Y, Ferguson DJ, et al. (2006). «The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.». J. Cell. Biochem. 99 (5): 1380–96. PMID 16924678. doi:10.1002/jcb.20965*Chan JY, Lee-Prudhoe JE, Jorgensen B, et al. (2001). «Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.». J. Biol. Chem. 276 (3): 2139–52. PMID 11027692. doi:10.1074/jbc.M007965200*Ganesh SK, Zakai NA, van Rooij FJ, et al. (2009). «Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium». Nat. Genet. 41 (11): 1191–8. PMC 2778265

. PMID 19862010. doi:10.1038/ng.466*Barbe L, Lundberg E, Oksvold P, et al. (2008). «Toward a confocal subcellular atlas of the human proteome». Mol. Cell. Proteomics. 7 (3): 499–508. PMID 18029348. doi:10.1074/mcp.M700325-MCP200*Kurosawa N, Kanemitsu Y, Matsui T, et al. (1999). «Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164». Eur. J. Biochem. 265 (1): 466–72. PMID 10491205. doi:10.1046/j.1432-1327.1999.00777.x*Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055*Doyonnas R, Yi-Hsin Chan J, Butler LH, et al. (2000). «CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor». J. Immunol. 165 (2): 840–51. PMID 10878358. doi:10.4049/jimmunol.165.2.840*Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). «Many sequence variants affecting diversity of adult human height». Nat. Genet. 40 (5): 609–15. PMID 18391951. doi:10.1038/ng.122*Bonaldo MF, Lennon G, Soares MB (1996). «Normalization and subtraction: two approaches to facilitate gene discovery». Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791*Oh JH, Yang JO, Hahn Y, et al. (2005). «Transcriptome analysis of human gastric cancer». Mamm. Genome. 16 (12): 942–54. PMID 16341674. doi:10.1007/s00335-005-0075-2*Havens AM, Jung Y, Sun YX, et al. (2006). «The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis». BMC Cancer. 6. 195 páginas. PMC 1557671

. PMID 16859559. doi:10.1186/1471-2407-6-195*Forde S, Tye BJ, Newey SE, et al. (2007). «Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells». Blood. 109 (5): 1825–33. PMID 17077324. doi:10.1182/blood-2006-05-023028*Strausberg RL, Feingold EA, Grouse LH, et al. (2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241

. PMID 12477932. doi:10.1073/pnas.242603899*Hennersdorf F, Florian S, Jakob A, et al. (2005). «Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation». Cell Res. 15 (5): 325–35. PMID 15916720. doi:10.1038/sj.cr.7290301

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[1] «Doenças geneticamente associadas a CD164 ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[pmid9680353-3] Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (Agosto de 1998). «CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21». Blood. 92 (3): 849–66. PMID 9680353

[pmid9763543-4] Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (Outubro de 1998). «The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis». Blood. 92 (8): 2613–28. PMID 9763543

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