"LIM Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.
| Descriptor ID |
D060588
|
| MeSH Number(s) |
D12.776.512
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "LIM Domain Proteins".
Below are MeSH descriptors whose meaning is more specific than "LIM Domain Proteins".
This graph shows the total number of publications written about "LIM Domain Proteins" by people in this website by year, and whether "LIM Domain Proteins" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 10 | 10 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 7 | 7 |
| 2005 | 0 | 6 | 6 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 10 | 10 |
| 2008 | 0 | 5 | 5 |
| 2009 | 0 | 9 | 9 |
| 2010 | 0 | 7 | 7 |
| 2011 | 3 | 5 | 8 |
| 2012 | 7 | 6 | 13 |
| 2013 | 4 | 2 | 6 |
| 2014 | 7 | 1 | 8 |
| 2015 | 7 | 1 | 8 |
| 2016 | 7 | 3 | 10 |
| 2017 | 2 | 4 | 6 |
| 2018 | 2 | 2 | 4 |
| 2019 | 5 | 0 | 5 |
| 2020 | 2 | 1 | 3 |
| 2021 | 4 | 3 | 7 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 2 | 3 |
Below are the most recent publications written about "LIM Domain Proteins" by people in Profiles.
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Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2. Elife. 2024 Dec 24; 12.
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Tandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments. Cell Rep. 2024 07 23; 43(7):114480.
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Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress. Nat Commun. 2024 Jun 10; 15(1):4945.
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The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus. Dev Biol. 2023 11; 503:10-24.
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FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. Circ Res. 2023 04 28; 132(9):1144-1161.
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Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy. Circulation. 2022 04 19; 145(16):1238-1253.
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Meta-analyses identify DNA methylation associated with kidney function and damage. Nat Commun. 2021 12 09; 12(1):7174.
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Mutation of the murine Prickle1 (R104Q) causes phenotypes analogous to human symptoms of epilepsy and autism. Exp Neurol. 2022 01; 347:113880.
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Effect of disease progression on the podocyte cell cycle in Alport Syndrome. Kidney Int. 2022 01; 101(1):106-118.
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Reducing body myopathy associated with the LIM2 p.(His123Arg) FHL1 variant. Clin Neurol Neurosurg. 2021 08; 207:106795.