"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
| Descriptor ID |
D058068
|
| MeSH Number(s) |
G05.695.224
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in this website by year, and whether "Endophenotypes" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 3 | 3 | 6 |
| 2011 | 3 | 7 | 10 |
| 2012 | 5 | 3 | 8 |
| 2013 | 3 | 5 | 8 |
| 2014 | 12 | 9 | 21 |
| 2015 | 8 | 6 | 14 |
| 2016 | 7 | 7 | 14 |
| 2017 | 1 | 6 | 7 |
| 2018 | 4 | 6 | 10 |
| 2019 | 5 | 1 | 6 |
| 2020 | 2 | 2 | 4 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 3 | 3 |
| 2024 | 3 | 5 | 8 |
Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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Effects of brain microRNAs in cognitive trajectory and Alzheimer's disease. Acta Neuropathol. 2024 Oct 30; 148(1):59.
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CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET. Nat Commun. 2024 Sep 20; 15(1):8251.
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Biomarkers and Endophenotypes of Post-traumatic Headaches. Curr Pain Headache Rep. 2024 Dec; 28(12):1185-1193.
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Novel N100 area reliably captures aberrant sensory processing and is associated with neurocognition in early psychosis. Schizophr Res. 2024 09; 271:71-80.
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Discovering the gene-brain-behavior link in autism via generative machine learning. Sci Adv. 2024 Jun 14; 10(24):eadl5307.
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Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson's disease. Commun Biol. 2024 05 15; 7(1):570.
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Dimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning. Biol Psychiatry. 2024 Oct 01; 96(7):564-584.
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Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories. Sci Transl Med. 2024 Mar 27; 16(740):eade8560.
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Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis. Mol Psychiatry. 2024 Aug; 29(8):2389-2398.
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Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement. 2024 02; 20(2):1268-1283.