"Holoenzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Catalytically active enzymes that are formed by the combination of an apoenzyme (APOENZYMES) and its appropriate cofactors and prosthetic groups.
| Descriptor ID |
D020035
|
| MeSH Number(s) |
D08.811.255
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Holoenzymes".
Below are MeSH descriptors whose meaning is more specific than "Holoenzymes".
This graph shows the total number of publications written about "Holoenzymes" by people in this website by year, and whether "Holoenzymes" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 1 | 4 | 5 |
| 2005 | 1 | 2 | 3 |
| 2006 | 1 | 5 | 6 |
| 2007 | 1 | 4 | 5 |
| 2009 | 0 | 3 | 3 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 3 | 4 |
| 2012 | 0 | 6 | 6 |
| 2013 | 1 | 4 | 5 |
| 2014 | 2 | 2 | 4 |
| 2015 | 0 | 3 | 3 |
| 2016 | 2 | 1 | 3 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 2 | 2 |
Below are the most recent publications written about "Holoenzymes" by people in Profiles.
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Direct visualization of translesion DNA synthesis polymerase IV at the replisome. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2208390119.
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Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. Nature. 2022 08; 608(7924):813-818.
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Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network. Nat Chem Biol. 2021 05; 17(5):558-566.
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The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex. Structure. 2021 05 06; 29(5):467-478.e6.
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Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. PLoS Biol. 2020 12; 18(12):e3001018.
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Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Am J Hum Genet. 2020 11 05; 107(5):977-988.
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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors. Sci Rep. 2019 11 04; 9(1):15893.
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Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16347-16356.
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The final steps of [FeFe]-hydrogenase maturation. Proc Natl Acad Sci U S A. 2019 08 06; 116(32):15802-15810.
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Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα. Structure. 2019 05 07; 27(5):816-828.e4.