Directed Molecular Evolution
"Directed Molecular Evolution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.
| Descriptor ID |
D019020
|
| MeSH Number(s) |
E05.393.420.175
|
| Concept/Terms |
Directed Molecular Evolution- Directed Molecular Evolution
- Directed Molecular Evolutions
- Evolution, Directed Molecular
- Evolutions, Directed Molecular
- Molecular Evolutions, Directed
- Molecular Evolution, Directed
- Evolution, Molecular, Directed
In Vitro Molecular Evolution- In Vitro Molecular Evolution
- Laboratory Molecular Evolution
- Evolution, Laboratory Molecular
- Evolutions, Laboratory Molecular
- Laboratory Molecular Evolutions
- Molecular Evolution, Laboratory
- Molecular Evolutions, Laboratory
|
Below are MeSH descriptors whose meaning is more general than "Directed Molecular Evolution".
Below are MeSH descriptors whose meaning is more specific than "Directed Molecular Evolution".
This graph shows the total number of publications written about "Directed Molecular Evolution" by people in this website by year, and whether "Directed Molecular Evolution" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 3 | 4 |
| 2003 | 3 | 1 | 4 |
| 2004 | 5 | 2 | 7 |
| 2005 | 2 | 0 | 2 |
| 2006 | 4 | 2 | 6 |
| 2007 | 2 | 1 | 3 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 4 | 6 |
| 2010 | 6 | 5 | 11 |
| 2011 | 2 | 5 | 7 |
| 2012 | 1 | 6 | 7 |
| 2013 | 2 | 3 | 5 |
| 2014 | 8 | 6 | 14 |
| 2015 | 0 | 3 | 3 |
| 2016 | 8 | 3 | 11 |
| 2017 | 6 | 0 | 6 |
| 2018 | 5 | 2 | 7 |
| 2019 | 8 | 1 | 9 |
| 2020 | 4 | 5 | 9 |
| 2021 | 1 | 3 | 4 |
| 2022 | 1 | 0 | 1 |
| 2024 | 3 | 3 | 6 |
Below are the most recent publications written about "Directed Molecular Evolution" by people in Profiles.
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Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science. 2024 Nov 29; 386(6725):eadk9893.
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Rooting for success: Evolutionary enhancement of Bacillus for superior plant colonization. Microb Biotechnol. 2024 09; 17(9):e70001.
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Directed evolution of hyperactive integrases for site specific insertion of transgenes. Nucleic Acids Res. 2024 Aug 12; 52(14):e64.
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Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening. ACS Synth Biol. 2024 Jul 19; 13(7):2215-2226.
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Evolution and engineering of pathways for aromatic O-demethylation in Pseudomonas putida KT2440. Metab Eng. 2024 Jul; 84:145-157.
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Proteome partitioning constraints in long-term laboratory evolution. Nat Commun. 2024 May 14; 15(1):4087.
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Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance. Elife. 2022 01 11; 11.
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Witnessing the structural evolution of an RNA enzyme. Elife. 2021 09 09; 10.
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Growth-Based, High-Throughput Selection for NADH Preference in an Oxygen-Dependent Biocatalyst. ACS Synth Biol. 2021 09 17; 10(9):2359-2370.
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Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis. Nat Commun. 2021 05 27; 12(1):3186.