"Patch-Clamp Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
| Descriptor ID |
D018408
|
| MeSH Number(s) |
E05.200.500.905 E05.242.800
|
| Concept/Terms |
Patch-Clamp Techniques- Patch-Clamp Techniques
- Patch Clamp Techniques
- Patch-Clamp Technique
- Technique, Patch-Clamp
- Techniques, Patch-Clamp
- Patch-Clamp Technics
- Patch Clamp Technics
- Patch-Clamp Technic
- Technic, Patch-Clamp
- Technics, Patch-Clamp
Whole-Cell Recording- Whole-Cell Recording
- Recording, Whole-Cell
- Recordings, Whole-Cell
- Whole Cell Recording
- Whole-Cell Recordings
Voltage-Clamp Techniques- Voltage-Clamp Techniques
- Technique, Voltage-Clamp
- Techniques, Voltage-Clamp
- Voltage Clamp Techniques
- Voltage-Clamp Technique
- Voltage-Clamp Technics
- Technic, Voltage-Clamp
- Technics, Voltage-Clamp
- Voltage Clamp Technics
- Voltage-Clamp Technic
|
Below are MeSH descriptors whose meaning is more general than "Patch-Clamp Techniques".
Below are MeSH descriptors whose meaning is more specific than "Patch-Clamp Techniques".
This graph shows the total number of publications written about "Patch-Clamp Techniques" by people in this website by year, and whether "Patch-Clamp Techniques" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 28 | 29 |
| 1996 | 0 | 54 | 54 |
| 1997 | 0 | 52 | 52 |
| 1998 | 0 | 62 | 62 |
| 1999 | 0 | 46 | 46 |
| 2000 | 1 | 47 | 48 |
| 2001 | 1 | 65 | 66 |
| 2002 | 0 | 76 | 76 |
| 2003 | 3 | 89 | 92 |
| 2004 | 0 | 64 | 64 |
| 2005 | 1 | 68 | 69 |
| 2006 | 4 | 68 | 72 |
| 2007 | 0 | 94 | 94 |
| 2008 | 1 | 79 | 80 |
| 2009 | 0 | 73 | 73 |
| 2010 | 3 | 88 | 91 |
| 2011 | 1 | 83 | 84 |
| 2012 | 1 | 70 | 71 |
| 2013 | 1 | 54 | 55 |
| 2014 | 0 | 46 | 46 |
| 2015 | 4 | 51 | 55 |
| 2016 | 3 | 39 | 42 |
| 2017 | 6 | 38 | 44 |
| 2018 | 0 | 28 | 28 |
| 2019 | 1 | 31 | 32 |
| 2020 | 1 | 29 | 30 |
| 2021 | 6 | 18 | 24 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 4 | 5 |
Below are the most recent publications written about "Patch-Clamp Techniques" by people in Profiles.
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A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules. ACS Chem Neurosci. 2024 Nov 20; 15(22):4171-4184.
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Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation. Nat Commun. 2024 Jul 31; 15(1):6468.
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Single-Cell Patch-Clamp/Proteomics of Human Alzheimer's Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets. Adv Sci (Weinh). 2024 Aug; 11(29):e2400545.
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Asymmetric Activation of ON and OFF Pathways in the Degenerated Retina. eNeuro. 2024 May; 11(5).
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Patch-seq: Multimodal Profiling of Single-Cell Morphology, Electrophysiology, and Gene Expression. Methods Mol Biol. 2024; 2752:227-243.
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Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid. Science. 2022 03 11; 375(6585):1177-1182.
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Ultrasound Mediated Cellular Deflection Results in Cellular Depolarization. Adv Sci (Weinh). 2022 01; 9(2):e2101950.
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Protocol to assess two distinct components of the nonlinear capacitance in mouse cardiomyocytes. STAR Protoc. 2021 12 17; 2(4):100891.
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Disruption of protein quality control of the human ether-à-go-go related gene K+ channel results in profound long QT syndrome. Heart Rhythm. 2022 02; 19(2):281-292.
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The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter. Elife. 2021 08 31; 10.