"Protein Prenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.
| Descriptor ID |
D017368
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| MeSH Number(s) |
G02.111.660.871.790.600.400 G02.111.672.500 G02.111.691.600.400 G03.734.871.790.600.400 G03.804.500 G05.308.670.600.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Prenylation".
Below are MeSH descriptors whose meaning is more specific than "Protein Prenylation".
This graph shows the total number of publications written about "Protein Prenylation" by people in this website by year, and whether "Protein Prenylation" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 1 | 5 | 6 |
| 2001 | 1 | 2 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 4 | 5 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 5 | 6 |
| 2007 | 0 | 2 | 2 |
| 2009 | 1 | 2 | 3 |
| 2010 | 0 | 5 | 5 |
| 2011 | 2 | 4 | 6 |
| 2012 | 0 | 1 | 1 |
| 2013 | 3 | 1 | 4 |
| 2014 | 0 | 1 | 1 |
| 2015 | 2 | 2 | 4 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 2 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Protein Prenylation" by people in Profiles.
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Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation. ACS Chem Biol. 2022 10 21; 17(10):2945-2953.
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A prenylated dsRNA sensor protects against severe COVID-19. Science. 2021 Oct 29; 374(6567):eabj3624.
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Characterization of Prenylated C-terminal Peptides Using a Thiopropyl-based Capture Technique and LC-MS/MS. Mol Cell Proteomics. 2020 06; 19(6):1005-1016.
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KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner. Biophys J. 2019 03 19; 116(6):1049-1063.
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Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins. Cancer Res. 2018 03 01; 78(5):1347-1357.
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Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. ACS Chem Biol. 2017 07 21; 12(7):1956-1962.
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Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5503-5508.
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Post translational modifications of Rab GTPases. Small GTPases. 2018 03 04; 9(1-2):49-56.
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Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6766-E6775.
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Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. Nat Chem. 2016 12; 8(12):1152-1158.