"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 6 | 3 | 9 |
| 1996 | 5 | 6 | 11 |
| 1997 | 2 | 8 | 10 |
| 1998 | 1 | 6 | 7 |
| 1999 | 1 | 11 | 12 |
| 2000 | 3 | 3 | 6 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 9 | 10 |
| 2003 | 1 | 7 | 8 |
| 2004 | 1 | 3 | 4 |
| 2005 | 1 | 7 | 8 |
| 2006 | 0 | 5 | 5 |
| 2007 | 2 | 3 | 5 |
| 2008 | 1 | 5 | 6 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 4 | 4 |
| 2011 | 2 | 7 | 9 |
| 2012 | 1 | 7 | 8 |
| 2013 | 0 | 2 | 2 |
| 2014 | 2 | 8 | 10 |
| 2015 | 1 | 2 | 3 |
| 2016 | 0 | 4 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 2 | 3 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 2 | 2 |
Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory. J Neurosci. 2024 Dec 11; 44(50).
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Bioenergetic and excitotoxic determinants of cofilactin rod formation. J Neurochem. 2024 05; 168(5):899-909.
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Glutamate's Effects on the N-Methyl-D-Aspartate (NMDA) Receptor Ion Channel in Alzheimer's Disease Brain: Challenges for PET Radiotracer Development for Imaging the NMDA Ion Channel. Molecules. 2023 Dec 19; 29(1).
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Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats. Neurobiol Dis. 2022 08; 170:105756.
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Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D1 but not nicotinic agonist. Psychopharmacology (Berl). 2021 Apr; 238(4):979-990.
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The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia. Int J Mol Sci. 2020 Dec 22; 22(1).
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The D2-family receptor agonist bromocriptine but, not nicotine, reverses NMDA receptor antagonist-induced working memory deficits in the radial arm maze in mice. Neurobiol Learn Mem. 2020 02; 168:107159.
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Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration. Exp Neurol. 2020 03; 325:113161.
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A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia. Neurochem Res. 2019 Nov; 44(11):2536-2545.
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Incomplete block of NMDA receptors by intracellular MK-801. Neuropharmacology. 2018 12; 143:122-129.