"Complement C1q" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
| Descriptor ID |
D015922
|
| MeSH Number(s) |
D12.776.124.486.274.050.270
|
| Concept/Terms |
Complement C1q- Complement C1q
- C1q, Complement
- Complement Component 1q
- Component 1q, Complement
- C1q Complement
- Complement, C1q
- Complement 1q
|
Below are MeSH descriptors whose meaning is more general than "Complement C1q".
Below are MeSH descriptors whose meaning is more specific than "Complement C1q".
This graph shows the total number of publications written about "Complement C1q" by people in this website by year, and whether "Complement C1q" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 4 | 2 | 6 |
| 1996 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 3 | 0 | 3 |
| 1999 | 4 | 1 | 5 |
| 2000 | 2 | 3 | 5 |
| 2001 | 3 | 1 | 4 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 3 | 1 | 4 |
| 2006 | 4 | 2 | 6 |
| 2007 | 3 | 1 | 4 |
| 2008 | 3 | 1 | 4 |
| 2009 | 3 | 3 | 6 |
| 2010 | 3 | 1 | 4 |
| 2011 | 5 | 0 | 5 |
| 2012 | 3 | 1 | 4 |
| 2013 | 3 | 1 | 4 |
| 2014 | 3 | 1 | 4 |
| 2015 | 1 | 4 | 5 |
| 2016 | 4 | 2 | 6 |
| 2017 | 4 | 4 | 8 |
| 2018 | 1 | 3 | 4 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 4 | 1 | 5 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 4 | 0 | 4 |
Below are the most recent publications written about "Complement C1q" by people in Profiles.
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Hematopoietic Stem Cell Transplantation for C1q Deficiency: A Study on Behalf of the EBMT Inborn Errors Working Party. J Clin Immunol. 2024 10 29; 45(1):35.
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Interrogating post-transplant donor HLA-specific antibody characteristics and effector functions using clinical bead assays. Hum Immunol. 2024 Nov; 85(6):111094.
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Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response. Arthritis Rheumatol. 2024 Nov; 76(11):1611-1622.
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Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function. J Neurochem. 2024 Sep; 168(9):3095-3107.
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Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer's mouse models. J Neuroinflammation. 2023 Sep 19; 20(1):211.
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Brief report on the relation between complement C3a and anti dsDNA antibody in systemic lupus erythematosus. Sci Rep. 2022 05 02; 12(1):7098.
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Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients. Ann Transplant. 2021 Dec 01; 26:e934175.
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C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex. Glia. 2022 03; 70(3):451-465.
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Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury. Science. 2021 Sep 10; 373(6560):eabj2685.
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Impact of C1q fixing donor-specific antibodies on renal transplant outcome. Scand J Immunol. 2021 Jul; 94(1):e13048.