"Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
| Descriptor ID |
D014475
|
| MeSH Number(s) |
D27.505.519.389.936
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Agents".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Agents".
This graph shows the total number of publications written about "Uncoupling Agents" by people in this website by year, and whether "Uncoupling Agents" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 2 | 1 | 3 |
| 1998 | 2 | 2 | 4 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 6 | 6 |
| 2001 | 1 | 1 | 2 |
| 2002 | 2 | 6 | 8 |
| 2003 | 1 | 4 | 5 |
| 2004 | 1 | 3 | 4 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 3 | 5 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Uncoupling Agents" by people in Profiles.
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Postictal hypoxia involves reactive oxygen species and is ameliorated by chronic mitochondrial uncoupling. Neuropharmacology. 2023 11 01; 238:109653.
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4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response. J Neurosci. 2020 11 04; 40(45):8734-8745.
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TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 01 27; 64(2).
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat Commun. 2017 12 12; 8(1):2068.
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A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents. Mitochondrion. 2016 Nov; 31:79-83.
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Antiinfectives targeting enzymes and the proton motive force. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7073-82.
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Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. J Neural Transm (Vienna). 2015 Jun; 122(6):741-6.
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Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. Mol Cell. 2013 Jun 27; 50(6):831-43.
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A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One. 2012; 7(5):e33023.
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Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 2012; 159(1):23-32.