Alexandra Nelson, MD, PhD
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Title(s) | Associate Professor, Neurology |
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School | School of Medicine |
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Pronouns | she/her/hers |
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vCard | Download vCard |
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Title(s) | UCSF Weill Institute for Neurosciences |
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Biography
UC San Diego | Ph.D. | 2006 | |
UC San Diego School of Medicine | | 2006 | |
UCSF | Residency | 2010 | Neurology |
Gladstone Institutes | Fellowship | 2014 | |
Overview
Dr. Alexandra Nelson is a neurologist who cares for patients with disorders that affect both movement and cognition, such as Huntington's disease, spinocerebellar ataxia and atypical parkinsonism. She also works closely with her patients' families. She is a member of the clinical and research team at UCSF's Memory and Aging Center and Huntington's Disease Clinic, designated a center of excellence by the Huntington's Disease Society of America.
As both a neuroscientist and a behavioral neurologist, Nelson is particularly interested in understanding neurodegenerative movement disorders, conditions in which progressive nerve-cell degeneration can diminish mental as well as physical function. Her laboratory team studies the cells and circuits involved in movement disorders. Her research seeks to distinguish brain regions, cells and patterns of brain activity that promote normal movement from those that produce abnormal movement, allowing development of more focused treatments.
Nelson earned her medical degree and a doctorate in neuroscience at the University of California, San Diego, where she studied cerebellar motor learning. She then completed a residency in neurology at UCSF and a postdoctoral fellowship at the Gladstone Institutes, where she investigated specific neurological circuits involved in Parkinson's disease and dystonia, or abnormal muscle tone.
Nelson joined the UCSF faculty in 2014. She is the Richard and Shirley Cahill Endowed Chair in Parkinson's Disease Research. She belongs to the Society for Neuroscience, American Neurological Association, International Parkinson and Movement Disorder Society and Huntington Study Group.
Research
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Bibliographic
Altmetrics Details
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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TRANSIENT ALTERATIONS IN THALAMO-CEREBELLAR FUNCTIONAL CONNECTIVITY IN PREMANIFEST HUNTINGTON'S DISEASE. medRxiv. 2025 Jan 15.
Morrison MA, Yao J, Bhalerao R, Jakary A, Glueck J, Driscoll T, Geschwind MD, Nelson AB, Possin KL, Hess CP, Lupo JM. PMID: 39867412; PMCID: PMC11759595.
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Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia. bioRxiv. 2024 Nov 01.
Twedell EL, Bair-Marshall CJ, Girasole AE, Scaria LK, Sridhar S, Nelson AB. PMID: 39416118; PMCID: PMC11482940.
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Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson's Disease. bioRxiv. 2024 Nov 01.
Zhuang X, Lemak J, Sridhar S, Nelson AB. PMID: 39554037; PMCID: PMC11565822.
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Tau P301S Transgenic Mice Develop Gait and Eye Movement Impairments That Mimic Progressive Supranuclear Palsy. bioRxiv. 2024 Oct 31.
Creed RB, Harris SC, Sridhar S, du Lac S, Zee DS, Dunn FA, Bouvier G, Nelson AB. PMID: 39386710; PMCID: PMC11463522.
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Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input. Cell Rep. 2024 08 27; 43(8):114483.
Ryan MB, Girasole AE, Flores AJ, Twedell EL, McGregor MM, Brakaj R, Paletzki RF, Hnasko TS, Gerfen CR, Nelson AB. PMID: 39024096.
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2 Fields:
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Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration. bioRxiv. 2024 May 13.
Rademacher K, Doric Z, Haddad D, Mamaligas A, Liao SC, Creed RB, Kano K, Chatterton Z, Fu Y, Garcia JH, Vance V, Sei Y, Kreitzer A, Halliday GM, Nelson AB, Margolis EB, Nakamura K. PMID: 38645054; PMCID: PMC11030348.
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Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression. Exp Neurol. 2024 Apr; 374:114693.
Seiler JL, Zhuang X, Nelson AB, Lerner TN. PMID: 38242300.
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HumansCells
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Altered Iron and Microstructure in Huntington's Disease Subcortical Nuclei: Insight From 7T MRI. J Magn Reson Imaging. 2024 Oct; 60(4):1484-1499.
Yao J, Morrison MA, Jakary A, Avadiappan S, Rowley P, Glueck J, Driscoll T, Geschwind MD, Nelson AB, Possin KL, Xu D, Hess CP, Lupo JM. PMID: 38206986; PMCID: PMC11521114.
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Humans
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The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias. Cerebellum. 2024 Aug; 23(4):1411-1425.
Selvadurai LP, Perlman SL, Ashizawa T, Wilmot GR, Onyike CU, Rosenthal LS, Shakkottai VG, Paulson HL, Subramony SH, Bushara KO, Kuo SH, Dietiker C, Geschwind MD, Nelson AB, Gomez CM, Opal P, Zesiewicz TA, Hawkins T, Yacoubian TA, Nopoulos PC, Sha SJ, Morrison PE, Figueroa KP, Pulst SM, Schmahmann JD. PMID: 38165578; PMCID: PMC11217149.
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1 Fields:
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Humans
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Adaptor protein-3 produces synaptic vesicles that release phasic dopamine. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2309843120.
Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson AB, Silm K, Ford CP, Edwards RH. PMID: 37812725; PMCID: PMC10589613.
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4 Fields:
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Cells
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Comparison of quantitative susceptibility mapping methods for iron-sensitive susceptibility imaging at 7T: An evaluation in healthy subjects and patients with Huntington's disease. Neuroimage. 2023 01; 265:119788.
Yao J, Morrison MA, Jakary A, Avadiappan S, Chen Y, Luitjens J, Glueck J, Driscoll T, Geschwind MD, Nelson AB, Villanueva-Meyer JE, Hess CP, Lupo JM. PMID: 36476567; PMCID: PMC11588860.
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4 Fields:
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Humans
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The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications. Cerebellum. 2023 Oct; 22(5):790-809.
Selvadurai LP, Perlman SL, Wilmot GR, Subramony SH, Gomez CM, Ashizawa T, Paulson HL, Onyike CU, Rosenthal LS, Sair HI, Kuo SH, Ratai EM, Zesiewicz TA, Bushara KO, Öz G, Dietiker C, Geschwind MD, Nelson AB, Opal P, Yacoubian TA, Nopoulos PC, Shakkottai VG, Figueroa KP, Pulst SM, Morrison PE, Schmahmann JD. PMID: 35962273; PMCID: PMC10363993.
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1 Fields:
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Humans
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Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice. Elife. 2022 07 04; 11.
Schor JS, Gonzalez Montalvo I, Spratt PWE, Brakaj RJ, Stansil JA, Twedell EL, Bender KJ, Nelson AB. PMID: 35786442; PMCID: PMC9342952.
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11 Fields:
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Animals
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Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia. J Neurosci. 2022 03 30; 42(13):2835-2848.
Nelson AB, Girasole AE, Lee HY, Ptácek LJ, Kreitzer AC. PMID: 35165171; PMCID: PMC8973425.
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2 Fields:
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AnimalsCells
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NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).
Schonewille M, Girasole AE, Rostaing P, Mailhes-Hamon C, Ayon A, Nelson AB, Triller A, Casado M, De Zeeuw CI, Bouvier G. PMID: 34507990; PMCID: PMC8449340.
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16 Fields:
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HumansAnimalsCells
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Frontostriatal Projections Regulate Innate Avoidance Behavior. J Neurosci. 2021 06 23; 41(25):5487-5501.
Loewke AC, Minerva AR, Nelson AB, Kreitzer AC, Gunaydin LA. PMID: 34001628; PMCID: PMC8221601.
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11 Fields:
Translation:
Animals
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Directly to the Point: Dopamine Persistently Enhances Excitability of Direct Pathway Striatal Neurons. Neuron. 2020 04 22; 106(2):201-203.
McGregor MM, Nelson AB. PMID: 32325053.
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1 Fields:
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Cells
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A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders. Hum Mutat. 2020 02; 41(2):487-501.
Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, Hassin-Baer S, Poke G, Neas K, Geschwind MD, Grody WW, Gibbs R, Geschwind DH, Lupski JR, Below JE, Nelson SF, Fogel BL. PMID: 31692161; PMCID: PMC7182470.
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38 Fields:
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HumansCells
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Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons. Cell Rep. 2019 11 05; 29(6):1419-1428.e5.
McGregor MM, McKinsey GL, Girasole AE, Bair-Marshall CJ, Rubenstein JLR, Nelson AB. PMID: 31693884; PMCID: PMC6866662.
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32 Fields:
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AnimalsCells
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Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice. J Clin Invest. 2019 06 13; 129(9):3833-3838.
Schor JS, Nelson AB. PMID: 31194696; PMCID: PMC6715414.
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15 Fields:
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HumansAnimals
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Circuit Mechanisms of Parkinson's Disease. Neuron. 2019 03 20; 101(6):1042-1056.
McGregor MM, Nelson AB. PMID: 30897356.
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PubMed Mentions:
199 Fields:
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Humans
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Aberrant Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia. Cell Rep. 2018 06 19; 23(12):3438-3446.e5.
Ryan MB, Bair-Marshall C, Nelson AB. PMID: 29924988; PMCID: PMC6407866.
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59 Fields:
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AnimalsCells
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Expanding the global prevalence of spinocerebellar ataxia type 42. Neurol Genet. 2018 Jun; 4(3):e232.
Ngo K, Aker M, Petty LE, Chen J, Cavalcanti F, Nelson AB, Hassin-Baer S, Geschwind MD, Perlman S, Italiano D, Laganà A, Cavallaro S, Coppola G, Below JE, Fogel BL. PMID: 29629410; PMCID: PMC5886831.
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10
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A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia. Neuron. 2018 02 21; 97(4):787-795.e6.
Girasole AE, Lum MY, Nathaniel D, Bair-Marshall CJ, Guenthner CJ, Luo L, Kreitzer AC, Nelson AB. PMID: 29398356; PMCID: PMC6233726.
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54 Fields:
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AnimalsCells
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500 Fronto-Striatal Modulation of Anxiety-Like Behaviors. Biological Psychiatry. 2017 May 1; 81(10):s203.
Gunaydin GL, Nelson NA, Kreitzer KA. .
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BK Channels Are Required for Multisensory Plasticity in the Oculomotor System. Neuron. 2017 Jan 04; 93(1):211-220.
Nelson AB, Faulstich M, Moghadam S, Onori K, Meredith A, du Lac S. PMID: 27989457; PMCID: PMC5575767.
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11 Fields:
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AnimalsCells
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Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons. Neuron. 2016 07 06; 91(1):67-78.
Kharkwal G, Brami-Cherrier K, Lizardi-Ortiz JE, Nelson AB, Ramos M, Del Barrio D, Sulzer D, Kreitzer AC, Borrelli E. PMID: 27387649; PMCID: PMC4939839.
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49 Fields:
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AnimalsCells
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Pearls & Oy-sters: Episodic ataxia type 2: Case report and review of the literature. Neurology. 2016 06 07; 86(23):e239-41.
Guterman EL, Yurgionas B, Nelson AB. PMID: 27272039; PMCID: PMC4898315.
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9 Fields:
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Humans
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Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease. Neuron. 2015 Nov 18; 88(4):621-3.
Girasole AE, Nelson AB. PMID: 26590337.
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2 Fields:
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Animals
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Probing striatal microcircuitry to understand the functional role of cholinergic interneurons. Mov Disord. 2015 Sep; 30(10):1306-18.
Girasole AE, Nelson AB. PMID: 26227561; PMCID: PMC5942899.
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9 Fields:
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HumansAnimalsCells
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Striatal cholinergic neurotransmission requires VGLUT3. J Neurosci. 2014 Jun 25; 34(26):8772-7.
Nelson AB, Bussert TG, Kreitzer AC, Seal RP. PMID: 24966377; PMCID: PMC4069355.
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55 Fields:
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AnimalsCells
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Striatal cholinergic interneurons Drive GABA release from dopamine terminals. Neuron. 2014 Apr 02; 82(1):63-70.
Nelson AB, Hammack N, Yang CF, Shah NM, Seal RP, Kreitzer AC. PMID: 24613418; PMCID: PMC3976769.
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104 Fields:
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AnimalsCells
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Reassessing models of basal ganglia function and dysfunction. Annu Rev Neurosci. 2014; 37:117-35.
Nelson AB, Kreitzer AC. PMID: 25032493; PMCID: PMC4416475.
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PubMed Mentions:
139 Fields:
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HumansAnimals
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Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 01; 70(9):1158-66.
Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. PMID: 23835471; PMCID: PMC4013391.
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PubMed Mentions:
317 Fields:
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Humans
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Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One. 2012; 7(7):e40555.
Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. PMID: 22792368; PMCID: PMC3390383.
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PubMed Mentions:
60 Fields:
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AnimalsCells
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A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice. J Neurosci. 2012 Jul 04; 32(27):9119-23.
Nelson AB, Hang GB, Grueter BA, Pascoli V, Luscher C, Malenka RC, Kreitzer AC. PMID: 22764221; PMCID: PMC3420343.
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33 Fields:
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AnimalsCells
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Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. Alzheimer's & Dementia. 2012 Jul 1; 8(4):s747.
Andrews-Zwilling AY, Gillespie GA, Kravitz KA, Nelson NA, Devidze DN, Lo LI, Yoon YS, Bien-Ly BN, Ring RK, Zwilling ZD, Potter PG, Rubenstein RJ, Kreitzer KA, Huang HY. .
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Distinct roles of GABAergic interneurons in the regulation of striatal output pathways. J Neurosci. 2010 Feb 10; 30(6):2223-34.
Gittis AH, Nelson AB, Thwin MT, Palop JJ, Kreitzer AC. PMID: 20147549; PMCID: PMC2836801.
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204 Fields:
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AnimalsCells
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Speech-activated myoclonus masquerading as stuttering. Neurology. 2009 Jun 02; 72(22):1964.
Gelfand JM, Nelson AB, Fross RD, Glass GA. PMID: 19487657.
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Humans
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Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons. Neuron. 2005 May 19; 46(4):623-31.
Nelson AB, Gittis AH, du Lac S. PMID: 15944130.
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61 Fields:
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AnimalsCells
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Long-lasting increases in intrinsic excitability triggered by inhibition. Neuron. 2003 Oct 30; 40(3):609-20.
Nelson AB, Krispel CM, Sekirnjak C, du Lac S. PMID: 14642283.
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119 Fields:
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AnimalsCells
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Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neurons. J Neurophysiol. 2002 Apr; 87(4):2031-42.
Smith MR, Nelson AB, Du Lac S. PMID: 11929921.
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PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
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2002 | 1 |
2003 | 1 |
2005 | 1 |
2009 | 1 |
2010 | 1 |
2012 | 3 |
2013 | 1 |
2014 | 3 |
2015 | 2 |
2016 | 3 |
2017 | 1 |
2018 | 3 |
2019 | 4 |
2020 | 1 |
2021 | 2 |
2022 | 4 |
2023 | 1 |
2024 | 8 |
2025 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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