Positive Transcriptional Elongation Factor B
"Positive Transcriptional Elongation Factor B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.
| Descriptor ID |
D042925
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.626 D12.776.930.955.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Positive Transcriptional Elongation Factor B".
Below are MeSH descriptors whose meaning is more specific than "Positive Transcriptional Elongation Factor B".
This graph shows the total number of publications written about "Positive Transcriptional Elongation Factor B" by people in this website by year, and whether "Positive Transcriptional Elongation Factor B" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 1 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 5 | 2 | 7 |
| 2010 | 4 | 2 | 6 |
| 2011 | 4 | 3 | 7 |
| 2012 | 6 | 2 | 8 |
| 2013 | 4 | 0 | 4 |
| 2014 | 2 | 3 | 5 |
| 2015 | 1 | 3 | 4 |
| 2016 | 2 | 4 | 6 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 2 | 0 | 2 |
| 2023 | 2 | 0 | 2 |
| 2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Positive Transcriptional Elongation Factor B" by people in Profiles.
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Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster. Genetics. 2024 01 03; 226(1).
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7SK methylation by METTL3 promotes transcriptional activity. Sci Adv. 2023 05 10; 9(19):eade7500.
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P-TEFb: The master regulator of transcription elongation. Mol Cell. 2023 02 02; 83(3):393-403.
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P-TEFb is degraded by Siah1/2 in quiescent cells. Nucleic Acids Res. 2022 05 20; 50(9):5000-5013.
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Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol Cell. 2022 05 05; 82(9):1724-1736.e7.
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Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb. Elife. 2021 11 25; 10.
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Shape of promoter antisense RNAs regulates ligand-induced transcription activation. Nature. 2021 07; 595(7867):444-449.
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HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15763-15771.
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P-TEFb as A Promising Therapeutic Target. Molecules. 2020 Feb 14; 25(4).
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P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress. Mol Cell. 2019 04 18; 74(2):254-267.e10.