Somatic Hypermutation, Immunoglobulin
"Somatic Hypermutation, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.
| Descriptor ID |
D027041
|
| MeSH Number(s) |
G05.558.810 G12.500.780
|
| Concept/Terms |
Somatic Hypermutation, Immunoglobulin- Somatic Hypermutation, Immunoglobulin
- Hypermutation, Immunoglobulin Somatic
- Hypermutations, Immunoglobulin Somatic
- Immunoglobulin Somatic Hypermutations
- Somatic Hypermutations, Immunoglobulin
- Ig Somatic Hypermutation
- Immunoglobulin Somatic Hypermutation
- Hypermutation, Somatic, Immunoglobulin
- Somatic Hypermutation, Ig
- Hypermutation, Ig Somatic
- Hypermutations, Ig Somatic
- Ig Somatic Hypermutations
- Somatic Hypermutations, Ig
|
Below are MeSH descriptors whose meaning is more general than "Somatic Hypermutation, Immunoglobulin".
Below are MeSH descriptors whose meaning is more specific than "Somatic Hypermutation, Immunoglobulin".
This graph shows the total number of publications written about "Somatic Hypermutation, Immunoglobulin" by people in this website by year, and whether "Somatic Hypermutation, Immunoglobulin" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 |
| 2003 | 4 | 1 | 5 |
| 2004 | 1 | 2 | 3 |
| 2005 | 6 | 0 | 6 |
| 2006 | 4 | 1 | 5 |
| 2007 | 2 | 2 | 4 |
| 2008 | 0 | 2 | 2 |
| 2009 | 2 | 1 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 3 | 4 |
| 2015 | 4 | 2 | 6 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 2 | 3 |
| 2021 | 1 | 2 | 3 |
| 2022 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Somatic Hypermutation, Immunoglobulin" by people in Profiles.
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A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses. Nat Immunol. 2024 Aug; 25(8):1489-1506.
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Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization. Nucleic Acids Res. 2022 11 11; 50(20):11738-11754.
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Long-primed germinal centres with enduring affinity maturation and clonal migration. Nature. 2022 09; 609(7929):998-1004.
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The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination. DNA Repair (Amst). 2022 02; 110:103271.
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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 07; 35(7):2002-2016.
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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Science. 2021 05 14; 372(6543):738-741.
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Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells. Nat Commun. 2020 11 17; 11(1):5850.
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Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma. Am J Hematol. 2019 12; 94(12):1364-1373.
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Current insights into the mechanism of mammalian immunoglobulin class switch recombination. Crit Rev Biochem Mol Biol. 2019 08; 54(4):333-351.
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Shaping of infant B cell receptor repertoires by environmental factors and infectious disease. Sci Transl Med. 2019 02 27; 11(481).