"Isochromosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.
| Descriptor ID |
D018404
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| MeSH Number(s) |
A11.284.187.570 C23.550.210.430 G05.360.162.570 G05.365.590.175.430
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Isochromosomes".
Below are MeSH descriptors whose meaning is more specific than "Isochromosomes".
This graph shows the total number of publications written about "Isochromosomes" by people in this website by year, and whether "Isochromosomes" was a major or minor topic of these publications.
Below are the most recent publications written about "Isochromosomes" by people in Profiles.
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Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification. Mol Cell. 2015 Nov 05; 60(3):500-8.
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Clinical outcome: a monosomy 18p is better than a tetrasomy 18p. Cytogenet Genome Res. 2014; 144(4):294-8.
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Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10). Am J Hematol. 2014 Aug; 89(8):862.
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Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor. Cancer Genet. 2014 Apr; 207(4):153-9.
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Utility of SNP arrays in detecting, quantifying, and determining meiotic origin of tetrasomy 12p in blood from individuals with Pallister-Killian syndrome. Am J Med Genet A. 2012 Dec; 158A(12):3046-53.
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Early recurrence in standard-risk medulloblastoma patients with the common idic(17)(p11.2) rearrangement. Neuro Oncol. 2012 Jul; 14(7):831-40.
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Complete isochromosome 5p in one fetus of a monochorionic twin pair. Prenat Diagn. 2011 Jun; 31(6):605-7.
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Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. BMC Genet. 2008 Jan 04; 9:2.
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Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer Res. 2005 Jul 01; 11(13):4733-40.
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Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster. J Neurogenet. 2005 Apr-Jun; 19(2):57-85.