"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
|
| MeSH Number(s) |
E05.393.420.601
|
| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
|
Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 4 | 7 | 11 |
| 1996 | 4 | 2 | 6 |
| 1997 | 6 | 4 | 10 |
| 1998 | 12 | 6 | 18 |
| 1999 | 2 | 9 | 11 |
| 2000 | 8 | 5 | 13 |
| 2001 | 11 | 10 | 21 |
| 2002 | 9 | 10 | 19 |
| 2003 | 16 | 7 | 23 |
| 2004 | 13 | 8 | 21 |
| 2005 | 18 | 11 | 29 |
| 2006 | 18 | 10 | 28 |
| 2007 | 11 | 10 | 21 |
| 2008 | 10 | 18 | 28 |
| 2009 | 14 | 11 | 25 |
| 2010 | 14 | 12 | 26 |
| 2011 | 18 | 11 | 29 |
| 2012 | 22 | 13 | 35 |
| 2013 | 10 | 17 | 27 |
| 2014 | 15 | 15 | 30 |
| 2015 | 12 | 14 | 26 |
| 2016 | 12 | 18 | 30 |
| 2017 | 19 | 15 | 34 |
| 2018 | 16 | 25 | 41 |
| 2019 | 14 | 18 | 32 |
| 2020 | 27 | 17 | 44 |
| 2021 | 8 | 11 | 19 |
| 2022 | 2 | 8 | 10 |
| 2023 | 0 | 2 | 2 |
| 2024 | 6 | 11 | 17 |
| 2025 | 0 | 1 | 1 |
Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Design of a light and Ca2+ switchable organic-peptide hybrid. Proc Natl Acad Sci U S A. 2025 Feb 04; 122(5):e2411316122.
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Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM. Proc Natl Acad Sci U S A. 2025 Jan 07; 122(1):e2409030121.
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A synthetic protein-level neural network in mammalian cells. Science. 2024 Dec 13; 386(6727):1243-1250.
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Encoding extracellular modification of artificial cell membranes using engineered self-translocating proteins. Nat Commun. 2024 Oct 30; 15(1):9363.
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Engineered odorant receptors illuminate the basis of odour discrimination. Nature. 2024 Nov; 635(8038):499-508.
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Implications of glycosylation for the development of selected cytokines and their derivatives for medical use. Biotechnol Adv. 2024 Dec; 77:108467.
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Robust genome and cell engineering via in vitro and in situ circularized RNAs. Nat Biomed Eng. 2025 Jan; 9(1):109-126.
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Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device. Nat Commun. 2024 Jul 27; 15(1):6326.
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An integrative approach to protein sequence design through multiobjective optimization. PLoS Comput Biol. 2024 Jul; 20(7):e1011953.
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Biospecific Chemistry for Covalent Linking of Biomacromolecules. Chem Rev. 2024 Jul 10; 124(13):8516-8549.