"Genes, ras" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
| Descriptor ID |
D011905
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.550
|
| Concept/Terms |
N-ras Genes- N-ras Genes
- Genes, N-ras
- N ras Genes
- N-ras Gene
- N-ras Oncogenes
- N ras Oncogenes
- N-ras Oncogene
v-Ha-ras Genes- v-Ha-ras Genes
- Gene, v-Ha-ras
- Genes, v-Ha-ras
- v Ha ras Genes
- v-Ha-ras Gene
v-Ki-ras Genes- v-Ki-ras Genes
- Gene, v-Ki-ras
- Genes, v-Ki-ras
- v Ki ras Genes
- v-Ki-ras Gene
Ha-ras Genes- Ha-ras Genes
- Gene, Ha-ras
- Genes, Ha-ras
- Ha ras Genes
- Ha-ras Gene
Ki-ras Genes- Ki-ras Genes
- Gene, Ki-ras
- Genes, Ki-ras
- Ki ras Genes
- Ki-ras Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, ras".
Below are MeSH descriptors whose meaning is more specific than "Genes, ras".
This graph shows the total number of publications written about "Genes, ras" by people in this website by year, and whether "Genes, ras" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 8 | 8 | 16 |
| 1996 | 9 | 5 | 14 |
| 1997 | 10 | 5 | 15 |
| 1998 | 6 | 6 | 12 |
| 1999 | 10 | 3 | 13 |
| 2000 | 12 | 9 | 21 |
| 2001 | 3 | 8 | 11 |
| 2002 | 8 | 9 | 17 |
| 2003 | 7 | 12 | 19 |
| 2004 | 9 | 6 | 15 |
| 2005 | 11 | 4 | 15 |
| 2006 | 13 | 11 | 24 |
| 2007 | 11 | 8 | 19 |
| 2008 | 7 | 12 | 19 |
| 2009 | 5 | 18 | 23 |
| 2010 | 11 | 8 | 19 |
| 2011 | 9 | 8 | 17 |
| 2012 | 8 | 11 | 19 |
| 2013 | 9 | 5 | 14 |
| 2014 | 6 | 8 | 14 |
| 2015 | 5 | 6 | 11 |
| 2016 | 4 | 4 | 8 |
| 2017 | 10 | 4 | 14 |
| 2018 | 4 | 3 | 7 |
| 2019 | 1 | 0 | 1 |
| 2020 | 3 | 3 | 6 |
| 2021 | 4 | 2 | 6 |
| 2022 | 1 | 7 | 8 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Genes, ras" by people in Profiles.
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The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations. Sci Rep. 2024 10 26; 14(1):25452.
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New insights into RAS in head and neck cancer. Biochim Biophys Acta Rev Cancer. 2023 11; 1878(6):188963.
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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth. Nat Cell Biol. 2023 Jan; 25(1):159-169.
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Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy. ACS Chem Biol. 2022 10 21; 17(10):2710-2715.
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Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. J Am Chem Soc. 2022 09 07; 144(35):15916-15921.
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Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes. Cell Rep. 2022 07 19; 40(3):111104.
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Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11). ESMO Open. 2022 06; 7(3):100512.
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Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022 05 26; 185(11):1905-1923.e25.
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Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma. Oncogene. 2022 05; 41(21):2973-2983.
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More to the RAS Story: KRASG12C Inhibition, Resistance Mechanisms, and Moving Beyond KRASG12C. Am Soc Clin Oncol Educ Book. 2022 Apr; 42:1-13.