Cholinesterase Reactivators
"Cholinesterase Reactivators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.
| Descriptor ID |
D002801
|
| MeSH Number(s) |
D27.505.519.405.347 D27.505.519.625.120.400 D27.505.696.577.120.400
|
| Concept/Terms |
Organophosphate Insecticide Antagonists- Organophosphate Insecticide Antagonists
- Antagonists, Organophosphate Insecticide
- Insecticide Antagonists, Organophosphate
- Insecticides, Organophosphate, Antagonists
|
Below are MeSH descriptors whose meaning is more general than "Cholinesterase Reactivators".
Below are MeSH descriptors whose meaning is more specific than "Cholinesterase Reactivators".
This graph shows the total number of publications written about "Cholinesterase Reactivators" by people in this website by year, and whether "Cholinesterase Reactivators" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2012 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
Below are the most recent publications written about "Cholinesterase Reactivators" by people in Profiles.
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A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides. J Neurochem. 2024 04; 168(4):370-380.
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Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. J Biol Chem. 2020 03 27; 295(13):4079-4092.
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Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures. Neurobiol Dis. 2020 01; 133:104455.
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ACMT Position Statement: Alternative or Contingency Countermeasures for Acetylcholinesterase Inhibiting Agents. J Med Toxicol. 2018 09; 14(3):261-263.
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New therapeutic approaches and novel alternatives for organophosphate toxicity. Toxicol Lett. 2018 Jul; 291:1-10.
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Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques. Toxicol Lett. 2018 Sep 01; 293:229-234.
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The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs. Chem Biol Interact. 2017 Nov 01; 277:159-167.
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Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017 Aug; 91(8):2837-2847.
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Modeling and simulation of organophosphate-induced neurotoxicity: Prediction and validation by experimental studies. Neurotoxicology. 2016 05; 54:140-152.
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Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. 2016 Mar; 90(3):603-16.