"Semaphorins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
| Descriptor ID |
D039961
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| MeSH Number(s) |
D12.644.276.923 D12.776.467.923 D23.529.923
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Semaphorins".
Below are MeSH descriptors whose meaning is more specific than "Semaphorins".
This graph shows the total number of publications written about "Semaphorins" by people in this website by year, and whether "Semaphorins" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 2 | 3 |
| 2004 | 4 | 2 | 6 |
| 2005 | 2 | 3 | 5 |
| 2006 | 3 | 2 | 5 |
| 2007 | 6 | 2 | 8 |
| 2008 | 3 | 2 | 5 |
| 2009 | 2 | 2 | 4 |
| 2010 | 3 | 2 | 5 |
| 2011 | 6 | 3 | 9 |
| 2012 | 1 | 0 | 1 |
| 2013 | 3 | 3 | 6 |
| 2014 | 1 | 0 | 1 |
| 2015 | 3 | 1 | 4 |
| 2016 | 6 | 0 | 6 |
| 2017 | 3 | 2 | 5 |
| 2018 | 0 | 1 | 1 |
| 2019 | 4 | 1 | 5 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2023 | 2 | 0 | 2 |
Below are the most recent publications written about "Semaphorins" by people in Profiles.
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Differential Requirement for Plexin-A3 and -A4 in Mediating Responses of Sensory and Sympathetic Neurons to Distinct Class 3 Semaphorins. Neuron. 2023 11 15; 111(22):3697.
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Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma. Nat Commun. 2023 04 20; 14(1):2262.
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Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome. Pediatr Neurol. 2022 01; 126:65-73.
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Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540).
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CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. EMBO Rep. 2020 03 04; 21(3):e48512.
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FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits. Hum Mol Genet. 2019 11 15; 28(22):3777-3791.
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Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers. Cancer Discov. 2020 01; 10(1):86-103.
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NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas. J Pathol. 2019 09; 249(1):90-101.
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Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation. J Neurosci. 2019 05 29; 39(22):4221-4237.
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Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin. Elife. 2019 02 08; 8.