"Chromosome Fragile Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
| Descriptor ID |
D043283
|
| MeSH Number(s) |
G05.360.340.024.189.610
|
| Concept/Terms |
Chromosome Fragile Sites- Chromosome Fragile Sites
- Chromosome Fragile Site
- Fragile Site, Chromosome
- Site, Chromosome Fragile
- Sites, Chromosome Fragile
- Fragile Sites, Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".
This graph shows the total number of publications written about "Chromosome Fragile Sites" by people in this website by year, and whether "Chromosome Fragile Sites" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Chromosome Fragile Sites" by people in Profiles.
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The RNA tether model for human chromosomal translocation fragile zones. Trends Biochem Sci. 2024 May; 49(5):391-400.
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Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage. Oncogene. 2020 02; 39(6):1260-1272.
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Concept of DNA Lesion Longevity and Chromosomal Translocations. Trends Biochem Sci. 2018 07; 43(7):490-498.
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Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes Dev. 2015 Apr 01; 29(7):690-5.
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Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr; 35(7):1209-22.
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CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity. Mol Cell. 2014 Jun 19; 54(6):1012-1021.
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One in four individuals of African-American ancestry harbors a 5.5kb deletion at chromosome 11q13.1. Genomics. 2014 Apr; 103(4):276-87.
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Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability. Genes Chromosomes Cancer. 2013 Nov; 52(11):1017-29.
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Identification of early replicating fragile sites that contribute to genome instability. Cell. 2013 Jan 31; 152(3):620-32.
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Comparative genomics reveals birth and death of fragile regions in mammalian evolution. Genome Biol. 2010; 11(11):R117.