"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 4 | 18 | 22 |
| 1996 | 2 | 25 | 27 |
| 1997 | 5 | 35 | 40 |
| 1998 | 12 | 33 | 45 |
| 1999 | 10 | 26 | 36 |
| 2000 | 12 | 47 | 59 |
| 2001 | 11 | 44 | 55 |
| 2002 | 13 | 93 | 106 |
| 2003 | 17 | 91 | 108 |
| 2004 | 17 | 99 | 116 |
| 2005 | 22 | 116 | 138 |
| 2006 | 16 | 134 | 150 |
| 2007 | 20 | 86 | 106 |
| 2008 | 18 | 116 | 134 |
| 2009 | 20 | 105 | 125 |
| 2010 | 19 | 110 | 129 |
| 2011 | 13 | 112 | 125 |
| 2012 | 25 | 109 | 134 |
| 2013 | 19 | 119 | 138 |
| 2014 | 12 | 87 | 99 |
| 2015 | 11 | 78 | 89 |
| 2016 | 16 | 75 | 91 |
| 2017 | 11 | 66 | 77 |
| 2018 | 14 | 59 | 73 |
| 2019 | 12 | 57 | 69 |
| 2020 | 8 | 50 | 58 |
| 2021 | 8 | 48 | 56 |
| 2022 | 3 | 10 | 13 |
| 2023 | 0 | 11 | 11 |
| 2024 | 3 | 3 | 6 |
| 2025 | 1 | 1 | 2 |
Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Mechanistic role of FN1 in LAIR-1 mediated downregulation of ovarian cancer cell proliferation. BMC Cancer. 2025 Feb 25; 25(1):339.
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Combination adjuvant improves influenza virus immunity by downregulation of immune homeostasis genes in lymphocytes. Immunohorizons. 2025 01 24; 9(2).
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Circulating microRNAs associated with bronchodilator response in childhood asthma. BMC Pulm Med. 2024 Nov 04; 24(1):553.
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The mitochondrial TSPO ligand Atriol mitigates metabolic-associated steatohepatitis by downregulating CXCL1. Metabolism. 2024 Oct; 159:155942.
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Differential Downregulation of β1-Adrenergic Receptor Signaling in the Heart. J Am Heart Assoc. 2024 Jun 18; 13(12):e033733.
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Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy. Acta Neuropathol. 2024 05 30; 147(1):93.
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Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail. Cancer Res Commun. 2024 03 08; 4(3):706-722.
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Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity. Exp Neurol. 2024 May; 375:114717.
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IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids. Cell Rep Med. 2024 01 16; 5(1):101352.
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Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. PLoS Genet. 2023 Nov; 19(11):e1011005.