"Spiro Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclic compounds that include two rings which share a single atom (usually a carbon). The simplest example of this type of compound is Spiro[2.2]pentane, which looks like a bow tie.
| Descriptor ID |
D013141
|
| MeSH Number(s) |
D02.455.426.779 D04.711
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Spiro Compounds".
Below are MeSH descriptors whose meaning is more specific than "Spiro Compounds".
This graph shows the total number of publications written about "Spiro Compounds" by people in this website by year, and whether "Spiro Compounds" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 2 | 1 | 3 |
| 2001 | 0 | 1 | 1 |
| 2003 | 4 | 0 | 4 |
| 2004 | 4 | 2 | 6 |
| 2005 | 4 | 1 | 5 |
| 2006 | 10 | 1 | 11 |
| 2007 | 9 | 2 | 11 |
| 2008 | 7 | 2 | 9 |
| 2009 | 7 | 1 | 8 |
| 2010 | 12 | 5 | 17 |
| 2011 | 8 | 1 | 9 |
| 2012 | 2 | 2 | 4 |
| 2013 | 4 | 1 | 5 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 1 | 3 |
| 2016 | 5 | 3 | 8 |
| 2017 | 4 | 1 | 5 |
| 2018 | 2 | 0 | 2 |
| 2019 | 5 | 1 | 6 |
| 2020 | 4 | 1 | 5 |
| 2021 | 5 | 1 | 6 |
| 2022 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Spiro Compounds" by people in Profiles.
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C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018-2023). Bioorg Chem. 2024 Feb; 143:107091.
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Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife. 2022 05 26; 11.
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Asymmetric Organocatalysis Enables Rapid Assembly of Portimine Precursor Chains. Org Lett. 2022 04 15; 24(14):2607-2612.
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Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance. J Antimicrob Chemother. 2021 10 11; 76(11):2847-2849.
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Atogepant for the Preventive Treatment of Migraine. N Engl J Med. 2021 08 19; 385(8):695-706.
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Dissipation kinetics and dietary risk assessment of spiromesifen on major summer vegetables using good agricultural practices. Biomed Chromatogr. 2021 Jul; 35(7):e5085.
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Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases. Bioorg Med Chem Lett. 2021 05 01; 39:127854.
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Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. J Med Chem. 2021 02 25; 64(4):2291-2309.
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Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice. Int J Mol Sci. 2021 Jan 13; 22(2).
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Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease. Alzheimers Dement. 2020 11; 16(11):1483-1492.