"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 18 | 3 | 21 |
| 1996 | 15 | 8 | 23 |
| 1997 | 14 | 6 | 20 |
| 1998 | 5 | 5 | 10 |
| 1999 | 8 | 6 | 14 |
| 2000 | 9 | 1 | 10 |
| 2001 | 7 | 2 | 9 |
| 2002 | 14 | 5 | 19 |
| 2003 | 8 | 5 | 13 |
| 2004 | 13 | 2 | 15 |
| 2005 | 9 | 2 | 11 |
| 2006 | 18 | 4 | 22 |
| 2007 | 19 | 6 | 25 |
| 2008 | 9 | 4 | 13 |
| 2009 | 17 | 5 | 22 |
| 2010 | 19 | 16 | 35 |
| 2011 | 24 | 7 | 31 |
| 2012 | 20 | 10 | 30 |
| 2013 | 19 | 6 | 25 |
| 2014 | 13 | 9 | 22 |
| 2015 | 14 | 7 | 21 |
| 2016 | 16 | 9 | 25 |
| 2017 | 14 | 8 | 22 |
| 2018 | 13 | 7 | 20 |
| 2019 | 8 | 9 | 17 |
| 2020 | 10 | 1 | 11 |
| 2021 | 14 | 4 | 18 |
| 2022 | 18 | 1 | 19 |
| 2023 | 19 | 0 | 19 |
| 2024 | 7 | 2 | 9 |
| 2025 | 0 | 1 | 1 |
Below are the most recent publications written about "Cocaine" by people in Profiles.
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Identification of Behavioral, Clinical, and Psychological Antecedents of Acute Stimulant Poisoning: Development and Implementation of a Mixed Methods Psychological Autopsy Study. JMIR Form Res. 2025 Jan 13; 9:e64873.
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Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct. Elife. 2024 Nov 01; 12.
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Prior cocaine use diminishes encoding of latent information by orbitofrontal, but not medial, prefrontal ensembles. Curr Biol. 2024 Nov 18; 34(22):5223-5238.e3.
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Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size. J Acquir Immune Defic Syndr. 2024 Oct 01; 97(2):156-164.
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High quality, high throughput, and low-cost simultaneous video recording of 60 animals in operant chambers using PiRATeMC. J Neurosci Methods. 2024 Nov; 411:110270.
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Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. Neuron. 2024 Oct 23; 112(20):3470-3485.e12.
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The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats. Psychopharmacology (Berl). 2024 Nov; 241(11):2303-2313.
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Brief Report: The Role of Substance Use in Structural Heart Disease Among Women Living With HIV. J Acquir Immune Defic Syndr. 2024 04 01; 95(4):342-346.
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Relapse to cocaine seeking is regulated by medial habenula NR4A2/NURR1 in mice. Cell Rep. 2024 03 26; 43(3):113956.
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Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats. Sci Rep. 2024 02 20; 14(1):4182.