"Anoctamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.
| Descriptor ID |
D000075368
|
| MeSH Number(s) |
D12.776.157.530.400.175.032 D12.776.543.550.450.175.032 D12.776.543.585.400.175.032
|
| Concept/Terms |
Anoctamins- Anoctamins
- Anoctamin
- TMEM16 Protein Family
- Protein Family, TMEM16
- TMEM16 Proteins
|
Below are MeSH descriptors whose meaning is more general than "Anoctamins".
Below are MeSH descriptors whose meaning is more specific than "Anoctamins".
This graph shows the total number of publications written about "Anoctamins" by people in this website by year, and whether "Anoctamins" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 5 | 0 | 5 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 2 | 0 | 2 |
| 2024 | 2 | 2 | 4 |
Below are the most recent publications written about "Anoctamins" by people in Profiles.
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Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families. Nat Struct Mol Biol. 2025 Feb; 32(2):222-236.
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SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling. Commun Biol. 2024 08 29; 7(1):1060.
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TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons. Proc Natl Acad Sci U S A. 2024 Jul 02; 121(27):e2311831121.
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Defining clinical endpoints in limb girdle muscular dystrophy: a GRASP-LGMD study. BMC Neurol. 2024 Mar 15; 24(1):96.
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ANO7 African-ancestral genomic diversity and advanced prostate cancer. Prostate Cancer Prostatic Dis. 2024 Sep; 27(3):558-565.
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Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun. 2023 08 12; 14(1):4874.
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Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes. Brain. 2022 04 18; 145(2):555-568.
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Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circ Genom Precis Med. 2021 12; 14(6):e003460.
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TMEM16K is an interorganelle regulator of endosomal sorting. Nat Commun. 2020 07 03; 11(1):3298.
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TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 09 04; 8.