Islet Amyloid Polypeptide
"Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
| Descriptor ID |
D058228
|
| MeSH Number(s) |
D06.472.699.587.334 D12.644.548.586.234 D12.776.049.407.500
|
| Concept/Terms |
Islet Amyloid Polypeptide- Islet Amyloid Polypeptide
- Amyloid Polypeptide, Islet
- Polypeptide, Islet Amyloid
- Pancreatic Amylin
- Amylin, Pancreatic
- IAPP Protein
- Insulinoma Amyloid Polypeptide
- Amyloid Polypeptide, Insulinoma
- Polypeptide, Insulinoma Amyloid
- Amlintide
- Amylin
|
Below are MeSH descriptors whose meaning is more general than "Islet Amyloid Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Islet Amyloid Polypeptide".
This graph shows the total number of publications written about "Islet Amyloid Polypeptide" by people in this website by year, and whether "Islet Amyloid Polypeptide" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 4 | 4 |
| 1997 | 0 | 5 | 5 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 7 | 7 |
| 2004 | 0 | 8 | 8 |
| 2005 | 0 | 5 | 5 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 12 | 12 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 9 | 9 |
| 2010 | 3 | 1 | 4 |
| 2011 | 1 | 2 | 3 |
| 2012 | 6 | 0 | 6 |
| 2013 | 4 | 1 | 5 |
| 2014 | 6 | 0 | 6 |
| 2015 | 4 | 2 | 6 |
| 2016 | 6 | 0 | 6 |
| 2017 | 5 | 2 | 7 |
| 2018 | 1 | 0 | 1 |
| 2019 | 6 | 0 | 6 |
| 2020 | 2 | 0 | 2 |
| 2021 | 3 | 2 | 5 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Islet Amyloid Polypeptide" by people in Profiles.
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Dysregulation of cholesterol homeostasis is an early signal of β-cell proteotoxicity characteristic of type 2 diabetes. Physiol Genomics. 2024 Sep 01; 56(9):621-633.
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Racemic Peptides from Amyloid β and Amylin Form Rippled β-Sheets Rather Than Pleated β-Sheets. J Am Chem Soc. 2023 11 29; 145(47):25917-25926.
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Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas. Commun Biol. 2023 01 03; 6(1):2.
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Peripherally administered amylin inhibits stress-like behaviors and enhances cognitive performance. Physiol Behav. 2022 02 01; 244:113668.
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Long-acting amylin analogue for weight reduction. Lancet. 2021 12 11; 398(10317):2132-2134.
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IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes. Diabetologia. 2022 01; 65(1):173-187.
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Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores. Nat Struct Mol Biol. 2021 09; 28(9):724-730.
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Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes. Commun Biol. 2021 05 19; 4(1):594.
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Effect of surface chemistry on islet amyloid polypeptide conformation. Biointerphases. 2020 09 04; 15(5):051001.
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Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat Struct Mol Biol. 2020 07; 27(7):653-659.