"Thrombasthenia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
| Descriptor ID |
D013915
|
| MeSH Number(s) |
C15.378.100.100.820 C15.378.140.810 C15.378.463.810 C16.320.099.820
|
| Concept/Terms |
Thrombasthenia- Thrombasthenia
- Thrombasthenias
- Thrombasthenia of Glanzmann and Naegeli
- Glanzmann Thrombasthenia
- Thrombasthenia, Glanzmann
Glanzmann Thrombasthenia, Type A- Glanzmann Thrombasthenia, Type A
- Platelet Fibrinogen Receptor, Deficiency of
- Platelet Glycoprotein IIb-IIIa Deficiency
- Platelet Glycoprotein IIb IIIa Deficiency
- Glycoprotein Complex IIb-IIIa, Deficiency Of
- Glycoprotein Complex IIb IIIa, Deficiency Of
- GP IIb-IIIa Complex, Deficiency Of
- GP IIb IIIa Complex, Deficiency Of
- Deficiency of GP 2b 3a Complex
- Platelet Glycoprotein 2b-3a Deficiency
- Platelet Glycoprotein 2b 3a Deficiency
|
Below are MeSH descriptors whose meaning is more general than "Thrombasthenia".
Below are MeSH descriptors whose meaning is more specific than "Thrombasthenia".
This graph shows the total number of publications written about "Thrombasthenia" by people in this website by year, and whether "Thrombasthenia" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 0 | 2 |
| 1998 | 2 | 1 | 3 |
| 2001 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2015 | 2 | 0 | 2 |
| 2020 | 3 | 0 | 3 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Thrombasthenia" by people in Profiles.
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A novel ITGA2B double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat. J Vet Intern Med. 2024 May-Jun; 38(3):1408-1417.
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Precision medicine identifies a pathogenic variant of the ITGA2B gene responsible for Glanzmann's thrombasthenia in a cat. J Vet Intern Med. 2020 Nov; 34(6):2438-2446.
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Successful Use of Hematopoietic Stem Cell Transplantation for 2 Pediatric Cases of Glanzmann Thrombasthenia and Review of the Literature. J Pediatr Hematol Oncol. 2020 08; 42(6):e521-e526.
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Genetics of equine bleeding disorders. Equine Vet J. 2021 Jan; 53(1):30-37.
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Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. J Vet Intern Med. 2015 Sep-Oct; 29(5):1387-94.
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Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. Hum Mutat. 2015 May; 36(5):548-61.
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Use of allogeneic stem cell transplantation for moderate-severe Glanzmann thrombasthenia. Platelets. 2015; 26(7):702-4.
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Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97.
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Hemosuccus pancreaticus in Glanzmann thrombasthenia: implication of scintigraphy in gastrointestinal bleeding (GIB) of unknown origin. Clin Nucl Med. 2011 Jul; 36(7):597-8.
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Platelet function defects. Haemophilia. 2008 Nov; 14(6):1240-9.