"Pregnanolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
| Descriptor ID |
D011280
|
| MeSH Number(s) |
D04.210.500.745.640
|
| Concept/Terms |
Pregnanolone- Pregnanolone
- 3 alpha-Hydroxy-5 beta-pregnan-20-one
- 3 alpha Hydroxy 5 beta pregnan 20 one
- alpha-Hydroxy-5 beta-pregnan-20-one, 3
- beta-pregnan-20-one, 3 alpha-Hydroxy-5
- 3-Hydroxypregnan-20-one
- 3 Hydroxypregnan 20 one
- Pregnanolone, (3alpha,5beta)-isomer
- Eltanolone
- Pregnan-3alpha-ol-20-one
- Pregnan 3alpha ol 20 one
- 3 alpha, 5 beta-Tetrahydroprogesterone
- 3 alpha, 5 beta Tetrahydroprogesterone
Sepranolone- Sepranolone
- Allopregnanolone
- 3 alpha-Hydroxy-5 alpha-pregnan-20-one
- 3 alpha Hydroxy 5 alpha pregnan 20 one
- alpha-Hydroxy-5 alpha-pregnan-20-one, 3
- alpha-pregnan-20-one, 3 alpha-Hydroxy-5
- Pregnanolone, (3alpha,5alpha)-isomer
Pregnanolone, (3beta, 5alpha)-isomer- Pregnanolone, (3beta, 5alpha)-isomer
- Allopregnan-3 beta-ol-20-one
- Allopregnan 3 beta ol 20 one
- beta-ol-20-one, Allopregnan-3
- 3beta-Hydroxy-5alpha-pregnan-20-one
- 3beta Hydroxy 5alpha pregnan 20 one
|
Below are MeSH descriptors whose meaning is more general than "Pregnanolone".
Below are MeSH descriptors whose meaning is more specific than "Pregnanolone".
This graph shows the total number of publications written about "Pregnanolone" by people in this website by year, and whether "Pregnanolone" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 7 | 2 | 9 |
| 2001 | 3 | 3 | 6 |
| 2002 | 3 | 0 | 3 |
| 2003 | 4 | 0 | 4 |
| 2004 | 5 | 4 | 9 |
| 2005 | 1 | 2 | 3 |
| 2006 | 5 | 1 | 6 |
| 2007 | 2 | 3 | 5 |
| 2008 | 3 | 1 | 4 |
| 2009 | 2 | 4 | 6 |
| 2010 | 3 | 1 | 4 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 2 | 4 |
| 2013 | 3 | 2 | 5 |
| 2014 | 2 | 3 | 5 |
| 2015 | 4 | 1 | 5 |
| 2016 | 1 | 1 | 2 |
| 2017 | 7 | 2 | 9 |
| 2018 | 3 | 0 | 3 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 3 | 1 | 4 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 2 | 3 |
| 2024 | 0 | 4 | 4 |
| 2025 | 1 | 1 | 2 |
Below are the most recent publications written about "Pregnanolone" by people in Profiles.
-
Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats. CNS Neurosci Ther. 2025 Mar; 31(3):e70215.
-
Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice. Int J Mol Sci. 2025 Jan 29; 26(3).
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Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial. Eur J Paediatr Neurol. 2024 Jul; 51:140-146.
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Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning. PLoS One. 2024; 19(6):e0304481.
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Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas. Cell. 2024 Jun 06; 187(12):2952-2968.e13.
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Cardiovascular responses of adult male Sprague-Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone. Arch Toxicol. 2024 04; 98(4):1177-1189.
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Long-term treatment with ganaxolone for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder: Two-year open-label extension follow-up. Epilepsia. 2024 Jan; 65(1):37-45.
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Structural insights into opposing actions of neurosteroids on GABAA receptors. Nat Commun. 2023 08 22; 14(1):5091.
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Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs. Epilepsia Open. 2023 06; 8(2):666-672.
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Ganaxolone versus Phenobarbital for Neonatal Seizure Management. Ann Neurol. 2022 12; 92(6):1066-1079.