[go: up one dir, main page]

Mansuri et al., 1989 - Google Patents

1-(2, 3-Dideoxy-. beta.-D-glycero-pent-2-enofuranosyl) thymine. A highly potent and selective anti-HIV agent

Mansuri et al., 1989

Document ID
9961003654604703660
Author
Mansuri M
Starrett Jr J
Ghazzouli I
Hitchcock M
Sterzycki R
Brankovan V
Lin T
August E
Prusoff W
Publication year
Publication venue
Journal of medicinal chemistry

External Links

Snippet

The nucleoside analogue l-(2, 3-dideoxy-/3-Dg (ycero-pent-2-enofuranosyl) thymine (d4T, 1) was prepared by ring opening of the 3', 5'-anhydro compound 5. This method has been refined such that it can be used toprepare d4T (1) on a large scale. The triphosphate of d4T …
Continue reading at pubs.acs.org (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System

Similar Documents

Publication Publication Date Title
Mansuri et al. 1-(2, 3-Dideoxy-. beta.-D-glycero-pent-2-enofuranosyl) thymine. A highly potent and selective anti-HIV agent
Kim et al. Potential anti-AIDS drugs. 2', 3'-Dideoxycytidine analogs
CA1333390C (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
US4788181A (en) 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
EP0980377B1 (en) Anti-viral pyrimidine nucleoside analogues
DE69503129T2 (en) PTERIDINE NUCLEOTIDE DERIVATIVES AS FLUORESCENT PROBE
US6211158B1 (en) Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents
Tanaka et al. Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogs of 1-[(2-hydroxyethoxy) methyl]-6-(phenylthio) thymine (HEPT)
IL89693A (en) Production of 2', 3'-dideoxy-2', 3'-didehydronucleosides
KR20030061792A (en) Nucleoside derivatives
EP0793669A1 (en) L-nucleoside dimer compounds and therapeutic uses
KR20110115601A (en) Purine nucleoside monophosphate prodrugs for the treatment of cancer and viral infections
JPH0662663B2 (en) Desazapurine-nucleoside-derivative
EP0788506A2 (en) L-ribofuranosyl nucleosides
WO1988008001A1 (en) Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
EP0409227A2 (en) Pyrimidine nucleosides, their preparation and pharmaceutical preparations
DE69031340T2 (en) ANTIVIRAL COMPOSITIONS CONTAINING 3'-AZIDO-2 ', 3'-DIDEOXY-5-METHYLCYTIDINE
KR100618028B1 (en) Nucleosides with anti-hepatitis hepatitis activity
Weis et al. L-ribofuranosyl nucleosides
DE69431304T2 (en) NUCLEOSIDES AND NUCLEOTIDES WITH ENLARGED RINGS
JPH10502655A (en) Dinucleoside-5 ', 5'-pyrophosphate
Warshaw et al. Nucleosides. 154. 2'-Azido-2', 3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus
US5153180A (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
Rios Morales et al. Diastereoselective Synthesis of cycloSaligenyl‐Nucleosyl‐Phosphotriesters
Ivanov et al. Bicyclic furano-, pyrrolo-, and thiopheno [2, 3-d] derivatives of pyrimidine nucleosides: Synthesis and antiviral properties