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Rubottom et al., 1983 - Google Patents

Preparation of methyl ketones by the sequential treatment of carboxylic acids with methyllithium and chlorotrimethylsilane

Rubottom et al., 1983

Document ID
9897844875939427413
Author
Rubottom G
Kim C
Publication year
Publication venue
The Journal of Organic Chemistry

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Snippet

One of the major problems associated with the trans-formation of carboxylic acids 1 into the corresponding methyl ketones 2 using methyllithium has been the co-rco2h 1, MeLl> RCOCH3+ RCOH (CH3) 2 1 2-h3+ 2 3 production of unwanted tertiary alcohols 3.1 If …
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